Bates D V
Department of Health Care and Epidemiology, University of British Columbia, Vancouver, Canada.
Environ Health Perspect. 1993 Dec;101 Suppl 4(Suppl 4):217-8. doi: 10.1289/ehp.93101s4217.
Studies in nonhuman primates indicate that one pathophysiologic consequence of ozone exposure is chronic bronchiolitis in terminal bronchioles. Modeling dosimetry suggests that a similar phenomenon is possible in humans. These findings may constitute an important analogy to the respiratory bronchiolitis that is associated with tobacco smoking in young adults. This analogy could form the basis for future research related to chronic respiratory health effects of ozone. The smoking data are reviewed and several research strategies are proposed that will be developed more fully in subsequent articles in this volume.
对非人类灵长类动物的研究表明，接触臭氧的一个病理生理后果是终末细支气管的慢性细支气管炎。剂量学模型表明，人类也可能出现类似现象。这些发现可能与年轻人吸烟相关的呼吸性细支气管炎构成重要类比。这种类比可为未来有关臭氧对慢性呼吸系统健康影响的研究奠定基础。本文回顾了吸烟数据，并提出了几种研究策略，这些策略将在本卷后续文章中更全面地展开。
