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Reaginic antibody production to protein antigens of Escherichia coli and Pseudomonas aeruginosa by mice.小鼠针对大肠杆菌和铜绿假单胞菌蛋白质抗原产生反应素抗体。
Infect Immun. 1976 Sep;14(3):694-702. doi: 10.1128/iai.14.3.694-702.1976.
2
Induction of reaginic (IgE) gonococcal antibodies in the rat by a common antigen of Neisseria gonorrhoeae.通过淋病奈瑟菌的一种共同抗原在大鼠中诱导产生反应素性（IgE）淋球菌抗体。
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Surveillance of gram-negative bacteria for Pseudomonas aeruginosa lipoprotein I using a monoclonal antibody.使用单克隆抗体对铜绿假单胞菌脂蛋白I进行革兰氏阴性菌监测。
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Pseudomonas aeruginosa antigens as potential vaccines.铜绿假单胞菌抗原作为潜在疫苗
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[Cell-free Pseudomonas vaccine. III. Immunochemical analysis of purified Pseudomonas aeruginosa protein antigens and protective properties of antisera against these antigens].[无细胞假单胞菌疫苗。III. 铜绿假单胞菌蛋白抗原的免疫化学分析及抗这些抗原血清的保护特性]
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Responses of human T cells to dominant discrete protein antigens of Escherichia coli and Pseudomonas aeruginosa.人类T细胞对大肠杆菌和铜绿假单胞菌主要离散蛋白抗原的反应。
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Systematic generation of antigen specific human monoclonal antibodies with therapeutical activities using active immunization.利用主动免疫系统生成具有治疗活性的抗原特异性人单克隆抗体。
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T lymphocyte responses to antigens of gram-negative bacteria in pyelonephritis.肾盂肾炎中T淋巴细胞对革兰氏阴性菌抗原的反应。
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Increased translocation of Escherichia coli and development of arthritis in vitamin A-deficient rats.维生素A缺乏大鼠中大肠杆菌易位增加及关节炎的发展。
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2
Specific Pseudomonas immunoglobulin E antibodies in sera of patients with cystic fibrosis.囊性纤维化患者血清中的特异性铜绿假单胞菌免疫球蛋白E抗体。
Infect Immun. 1981 May;32(2):967-8. doi: 10.1128/iai.32.2.967-968.1981.
3
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Development of enzyme linked immunosorbent assay (ELISA) to detect antibodies to Pseudomonas aeruginosa cell surface antigens in sera of patients with cystic fibrosis.开发酶联免疫吸附测定法（ELISA）以检测囊性纤维化患者血清中针对铜绿假单胞菌细胞表面抗原的抗体。
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6
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7
Homocytotropic antibodies (IgE) to Neisseria gonorrhoeae in the rat and a cross-reactivity of heterologous gonococcal strains.大鼠中针对淋病奈瑟菌的亲同种细胞性抗体（IgE）以及异源淋病菌株的交叉反应性。
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Prevention of experimental hematogenous and retrograde pyelonephritis by antibodies against enterobacterial common antigen.用针对肠杆菌共同抗原的抗体预防实验性血源和逆行性肾盂肾炎。
Infect Immun. 1970 Aug;2(2):175-82. doi: 10.1128/iai.2.2.175-182.1970.
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Studies on the O antigen of Salmonella typhosa. II. Immunological properties of the purified antigen.伤寒沙门氏菌O抗原的研究。II. 纯化抗原的免疫学特性。
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INHIBITION BY LIPOPOLYSACCHARIDE (ENDOTOXIN) OF ANTIBODY RESPONSE OF RABBIT TO COMMON ANTIGEN OF ENTEROBACTERIACEAE.脂多糖（内毒素）对兔针对肠杆菌科共同抗原的抗体反应的抑制作用
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Antigenic analysis of Salmonella typhosa and related salmonellas.伤寒沙门氏菌及相关沙门氏菌的抗原分析。
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6
Cell-mediated immunity and antibody responses in the respiratory tract after local and systemic immunization.局部和全身免疫后呼吸道中的细胞介导免疫和抗体反应。
J Exp Med. 1971 Aug 1;134(2):482-94. doi: 10.1084/jem.134.2.482.
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[On the common determinants of Enterobacteriaceae].[关于肠杆菌科的共同决定因素]
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The protein moiety of the endotoxin of Pseudomonas aeruginosa.铜绿假单胞菌内毒素的蛋白质部分。
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9
Effect of common enterobacterial antiserum on experimental Salmonella typhimurium infection of mice.普通肠杆菌抗血清对小鼠实验性鼠伤寒沙门氏菌感染的影响。
Proc Soc Exp Biol Med. 1971 Sep;137(4):1209-12. doi: 10.3181/00379727-137-35757.
10
Chemical characterization, spatial distribution and function of a lipoprotein (murein-lipoprotein) of the E. coli cell wall. The specific effect of trypsin on the membrane structure.大肠杆菌细胞壁脂蛋白（胞壁酰脂蛋白）的化学特性、空间分布及功能。胰蛋白酶对膜结构的特定作用。
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小鼠针对大肠杆菌和铜绿假单胞菌蛋白质抗原产生反应素抗体。

Reaginic antibody production to protein antigens of Escherichia coli and Pseudomonas aeruginosa by mice.

作者信息

Danneman P J, Michael J G

出版信息

Infect Immun. 1976 Sep;14(3):694-702. doi: 10.1128/iai.14.3.694-702.1976.

DOI:10.1128/iai.14.3.694-702.1976
PMID:823118
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC420942/
Abstract

Water-soluble antigens isolated from acetone-dried, gram-negative bacteria elicited reaginic antibody formation in mice. Antibodies specific for Escherichia coli antigens reacted with antigens isolated from several enterobacterial species tested, but not with antigens isolated from Pseudomonas aeruginosa. Reaginic antibodies induced by antigens isolated from a P. aeruginosa strain reacted with antigens isolated from several P.aeruginosa serotypes as well as with a purified protein component of the envelope of P. aeruginosa. The anti-Pseudomonas reagins did not cross-react with enterobacterial antigens. Antigenicity of the bacterial extracts was destroyed by trypsin treatment and reduced by heating, which suggested that the antigens were protein in nature. Whole bacterial cells adsorbed out reaginic antibodies, indicating that the antigens are located at or near the surface of the bacteria.

摘要

从丙酮干燥的革兰氏阴性菌中分离出的水溶性抗原能在小鼠体内引发反应素抗体的形成。对大肠杆菌抗原具有特异性的抗体与从几种受试肠杆菌科细菌中分离出的抗原发生反应，但不与从铜绿假单胞菌中分离出的抗原发生反应。由铜绿假单胞菌菌株分离出的抗原诱导产生的反应素抗体与从几种铜绿假单胞菌血清型中分离出的抗原以及与铜绿假单胞菌包膜的一种纯化蛋白成分发生反应。抗铜绿假单胞菌反应素不与肠杆菌科抗原发生交叉反应。细菌提取物的抗原性经胰蛋白酶处理后被破坏，经加热后降低，这表明抗原本质上是蛋白质。完整的细菌细胞能吸附反应素抗体，这表明抗原位于细菌表面或其附近。