Fort J G, Smith J B, Abruzzo J L
Division of Rheumatology, Jefferson Medical College, Philadelphia, PA.
Rheumatol Int. 1993;13(4):151-4. doi: 10.1007/BF00301262.
Psoriatic arthritis (PSA) is an inflammatory arthritis associated with psoriasis. Although not considered an autoimmune process, there is evidence for humoral and cellular immune abnormalities similar to autoimmune diseases such as rheumatoid arthritis and systemic lupus (SLE). We investigated mitogen-induced proliferation and interleukin 2 (IL-2) production by peripheral blood mononuclear cells in patients with PSA. Both IL-2 production and proliferation were significantly decreased in PSA patients when compared to controls. Increased arachidonic acid metabolism has been reported in skin and peripheral mononuclear cells of patients with psoriasis and PSA. We therefore also investigated the effect of indomethacin and prostaglandin E2 (PGE2) on IL-2 production. Addition of indomethacin to cultures did not significantly change IL-2 production in patients with PSA, but did so in controls. PGE2 produced a significant reduction in IL-2 production in PSA and in controls.
银屑病关节炎（PSA）是一种与银屑病相关的炎性关节炎。尽管它不被认为是自身免疫过程，但有证据表明其存在与类风湿关节炎和系统性红斑狼疮（SLE）等自身免疫性疾病相似的体液和细胞免疫异常。我们研究了PSA患者外周血单个核细胞在有丝分裂原诱导下的增殖及白细胞介素2（IL-2）的产生。与对照组相比，PSA患者的IL-2产生及增殖均显著降低。据报道，银屑病和PSA患者的皮肤及外周单个核细胞中花生四烯酸代谢增加。因此，我们还研究了吲哚美辛和前列腺素E2（PGE2）对IL-2产生的影响。在培养物中添加吲哚美辛对PSA患者的IL-2产生没有显著影响，但对对照组有显著影响。PGE2使PSA患者和对照组的IL-2产生均显著降低。
