Yamazaki T, Ishikawa T, Nakai H, Miyai M, Tsubota T, Asano K
Marugo Laboratory Service Center, Osaka, Japan.
J Chromatogr. 1993 May 19;615(1):180-5. doi: 10.1016/0378-4347(93)80307-p.
A determination method for the penicillin antibiotic aspoxicillin in broncho-alveolar lavage fluid has been developed, involving high-performance liquid chromatography and post-column photolysis. The method enabled the determination of aspoxicillin at concentrations below 100 ng/ml, with a linear calibration curve at concentrations of 1-1000 ng/ml for 100 microliters of lavage fluid. The detection limit was 1 ng/ml at a signal-to-noise ratio of 3:1.
已开发出一种用于测定支气管肺泡灌洗液中青霉素类抗生素阿扑西林的方法，该方法涉及高效液相色谱法和柱后光解。该方法能够测定浓度低于100 ng/ml的阿扑西林，对于100微升灌洗液，在1 - 1000 ng/ml的浓度范围内具有线性校准曲线。在信噪比为3:1时，检测限为1 ng/ml。
