Isemura M, Suzuki Y, Satoh K, Narumi K, Motomiya M
Laboratory of Biochemistry, School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Cell Biol Int. 1993 Jun;17(6):559-64. doi: 10.1006/cbir.1993.1099.
We studied the effects of 5 kinds of catechins on the adhesion of mouse lung carcinoma 3LL cells to the monolayer of bovine lung endothelial cells. (-)-Epicatechin gallate and (-)-epigallocatechin gallate were active in inhibiting the 3LL cell adhesion, while (+)-catechin and (-)-epicatechin were inactive. (-)-Epigallocatechin showed a considerable cytotoxicity. These data suggest that the specific chemical structure is required to exert the inhibitory activity of catechins and the search for the cellular binding protein(s) bound to these inhibitory catechins would provide a clue to clarify the mechanism of interactions between tumor cells and endothelial cells.
我们研究了5种儿茶素对小鼠肺癌3LL细胞与牛肺内皮细胞单层黏附的影响。（-）-表儿茶素没食子酸酯和（-）-表没食子儿茶素没食子酸酯具有抑制3LL细胞黏附的活性，而（+）-儿茶素和（-）-表儿茶素无此活性。（-）-表没食子儿茶素表现出相当大的细胞毒性。这些数据表明，儿茶素发挥抑制活性需要特定的化学结构，寻找与这些具有抑制作用的儿茶素结合的细胞结合蛋白将为阐明肿瘤细胞与内皮细胞之间的相互作用机制提供线索。
