Dagorn J C, Paradis D, Morisset J
Digestion. 1977 Feb;15(2):110-20. doi: 10.1159/000197992.
The response of amylase and chymotrypsinogen to a pancreatic secretory stimulation (intragastric administration of oleic acid or sodium oleate) are compared in rats. This comparison concerned the rates of biosynthesis of the two enzymes, their intrapancreatic levels of storage and their rates of excretion in the juice. In each of these 3 steps, it was found that the stimulation induced non-parallel courses of amylase and chymotrypsinogen. The non-parallelism in the rates of biosynthesis was found unable to explain the entire non-parallelism observed in the rates of excretion. These results suggest that the mechanism which controls the proportions of the different enzymes in the juice is different from that which monitors the rates of individual enzymes biosynthesis.
在大鼠中比较了淀粉酶和胰凝乳蛋白酶原对胰腺分泌刺激（胃内给予油酸或油酸钠）的反应。这种比较涉及两种酶的生物合成速率、它们在胰腺内的储存水平以及它们在胰液中的排泄速率。在这三个步骤中的每一个步骤中，都发现刺激诱导了淀粉酶和胰凝乳蛋白酶原的非平行变化过程。生物合成速率的非平行性无法解释排泄速率中观察到的整个非平行性。这些结果表明，控制胰液中不同酶比例的机制与监测单个酶生物合成速率的机制不同。
