匹兹堡1981年至1991年肝细胞癌肝移植的11年经验。
The 11-year Pittsburgh experience with liver transplantation for hepatocellular carcinoma: 1981-1991.
作者信息
Van Thiel D H, Carr B, Iwatsuki S, Selby R R, Fung J J, Starzl T E
机构信息
Pittsburgh Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, PA 15213.
出版信息
J Surg Oncol Suppl. 1993;3:78-82. doi: 10.1002/jso.2930530522.
Experience with liver transplantation over a period of 11 years at the University of Pittsburgh is presented. The application of liver transplantation to cases of hepatocellular carcinoma has changed considerably over this 11-year period with the sequential introduction of adjuvant and, more recently, neoadjuvant chemotherapy. Results with the combination of chemotherapy plus surgery appear to be better than results with either agent alone. Moreover, the early results with neoadjuvant therapy appear to be better than those achieved with adjuvant therapy. As a result of this experience, conceptual changes in the approach to the problem of hepatic cancer and the role of both chemotherapy and liver transplantation in its management have changed at the University of Pittsburgh. These changes are identified and discussed.
本文介绍了匹兹堡大学11年来的肝移植经验。在这11年期间，随着辅助化疗以及最近新辅助化疗的相继引入，肝移植在肝细胞癌病例中的应用发生了很大变化。化疗与手术联合应用的效果似乎优于单独使用任何一种治疗方法。此外，新辅助治疗的早期效果似乎优于辅助治疗。基于这一经验，匹兹堡大学对肝癌问题的处理方法以及化疗和肝移植在其治疗中的作用的观念发生了变化。本文对这些变化进行了识别和讨论。
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