Loguercio C, Taranto D, Beneduce F, del Vecchio Blanco C, de Vincentiis A, Nardi G, Romano M
Department of Internal Medicine-Gastrointestinal Pathophysiology, First Medical School, University of Naples, Italy.
Gut. 1993 Feb;34(2):161-5. doi: 10.1136/gut.34.2.161.
Whether parenteral administration of reduced glutathione prevented ethanol induced damage to and depletion of sulfhydryl compounds in the human gastric mucosa was investigated. Ten healthy volunteers underwent endoscopy on three separate occasions. Gastric mucosal damage was induced by spraying 80% ethanol on to the gastric mucosa through the biopsy channel of the endoscope. The gastric mucosal score, total sulfhydryls, glutathione, and cysteine were evaluated in basal conditions and after ethanol administration with and without pretreatment with parenteral glutathione. Glutathione significantly decreased the extent of ethanol induced macroscopic injury to the mucosa of the gastric body and antrum. Glutathione's protective effect is associated with appreciable inhibition of ethanol induced depletion of gastric sulfhydryl compounds. This is the first report of protection against ethanol induced gastric mucosal damage by a sulfhydryl containing agent in humans.
研究了胃肠外给予还原型谷胱甘肽是否能预防乙醇诱导的人胃黏膜巯基化合物的损伤和消耗。10名健康志愿者在三个不同时间接受了内镜检查。通过内镜活检通道向胃黏膜喷洒80%乙醇诱导胃黏膜损伤。在基础状态下以及乙醇给药后，分别评估有无胃肠外谷胱甘肽预处理时的胃黏膜评分、总巯基、谷胱甘肽和半胱氨酸。谷胱甘肽显著降低了乙醇诱导的胃体和胃窦黏膜宏观损伤程度。谷胱甘肽的保护作用与对乙醇诱导的胃巯基化合物消耗的明显抑制有关。这是关于含巯基药物对人类乙醇诱导的胃黏膜损伤具有保护作用的首篇报道。
