Petty R E, Steward M W
Immunology. 1977 Jan;32(1):49-55.
Inbred mice of a strain (B1OD2 new) known to produce either no detectable antibody or antibody of low affinity to two protein antigens administered in saline, were immunized with human serum transferrin (HST) in one of nine adjuvants. Such immunization increases the level and relative affinity of anti-HST antibody. The adjuvants used varied in the degree to which they augmented these parameters of the antibody response--that is, FCA and FIA were capable of inducing high levels of high affinity antibody, whereas other adjuvants elicited lower levels of high affinity antibody. The possibility is discussed that substances with adjuvant activity may effect antibody production at two stages: (1) at the stage of antigen selection of cells for proliferation and (2) at the stage or proliferation of antibody producing cell precursors.
已知某一品系（B1OD2新系）的近交系小鼠对在盐溶液中给予的两种蛋白质抗原不产生可检测到的抗体或产生低亲和力抗体，用九种佐剂之一中的人血清转铁蛋白（HST）对其进行免疫。这种免疫可提高抗HST抗体的水平和相对亲和力。所使用的佐剂在增强抗体反应这些参数的程度上有所不同——也就是说，弗氏完全佐剂（FCA）和弗氏不完全佐剂（FIA）能够诱导高水平的高亲和力抗体，而其他佐剂引发的高亲和力抗体水平较低。文中讨论了具有佐剂活性的物质可能在两个阶段影响抗体产生的可能性：（1）在细胞为增殖而进行抗原选择的阶段；（2）在抗体产生细胞前体的增殖阶段。
