唐松草中双苄基异喹啉类化合物唐松草碱的体外抗疟活性
In vitro antimalarial activity of penduline, a bisbenzylisoquinoline from Isopyrum thalictroides.
作者信息
Valentin A, Benoit-Vical F, Moulis C, Stanislas E, Mallié M, Fouraste I, Bastide J M
机构信息
Laboratoire d'Immunologie et Parasitologie, UFR Sciences Pharmaceutiques, Montpellier, France.
出版信息
Antimicrob Agents Chemother. 1997 Oct;41(10):2305-7. doi: 10.1128/AAC.41.10.2305.
Abstract
Two bisbenzylisoquinolines, tetrandrine and penduline, were purified from Isopyrum thalictroides. When tested for antimalarial activity in vitro, penduline was efficient at concentrations fivefold lower than those of tetrandrine. In highly synchronized parasite cultures, penduline mostly interfered between the 8th and the 32nd hours of the parasite cycle.
摘要
从唐松草中纯化出了两种双苄基异喹啉生物碱，粉防己碱和唐松草新碱。在体外抗疟活性测试中，唐松草新碱在浓度比粉防己碱低五倍时仍具有高效性。在高度同步化的寄生虫培养物中，唐松草新碱主要在寄生虫周期的第8至32小时之间产生干扰作用。
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