Alexander F E, McKinney P M, Cartwright R A
Leukaemia Research Fund Centre for Clinical Epidemiology (Universities of Leeds and Southampton), Southampton.
J Public Health Med. 1993 Mar;15(1):9-15. doi: 10.1093/oxfordjournals.pubmed.a042826.
As part of a more comprehensive study, complete residential histories were collected from 109 cases of childhood leukaemia and non-Hodgkin's lymphoma who were diagnosed while resident in Gateshead, West Cumbria or North Humberside (1973-1987), and who were born in the same areas. Corresponding data were obtained from the same number of controls matched by date of birth, sex and area of residence at diagnosis and birth. Altogether, 1332 years of residential history were available for analysis and of these 131 (9.8 per cent) included a change of home. Moving house was much more frequent for both cases and controls in the first two years of life (69 out of 432 child-years, i.e. 16 per cent). The moves were mostly over short distances, with only 23 per cent being 5 km or more and only 9 per cent into another administrative district. Twenty-eight per cent of the children had moved house at least once by their second birthday and 48 per cent by the age of five years. Few case-control differences were apparent and none achieved statistical significance. There was a suggestion of more mobility for case children in the first few years of life, especially for cases diagnosed shortly after the removal. When the residence of mothers in the year preceding the childrens' birth was examined, there were relatively few removals in this period (26, i.e. 24 per cent, altogether, of which 14 were over 5 km and nine from another administrative district). Of these, 18 case mothers had moved (11 over 5 km) compared with eight control mothers (three over 5 km).(ABSTRACT TRUNCATED AT 250 WORDS)
作为一项更全面研究的一部分,我们收集了109例儿童白血病和非霍奇金淋巴瘤患者的完整居住史,这些患者在盖茨黑德、西坎布里亚或北亨伯赛德居住期间被诊断出来(1973 - 1987年),且出生于同一地区。从相同数量的对照中获取了相应数据,这些对照按出生日期、性别以及诊断和出生时的居住地区进行匹配。总共1332年的居住史可供分析,其中131年(9.8%)包括搬家情况。病例组和对照组在生命的头两年搬家更为频繁(432个儿童年中有69次,即16%)。这些搬家大多距离较短,只有23%的距离为5公里或更远,仅有9%搬到另一个行政区。28%的儿童在两岁生日前至少搬过一次家,48%的儿童在五岁前搬过家。几乎没有明显的病例 - 对照差异,且无一达到统计学显著性。有迹象表明病例组儿童在生命的最初几年搬家更为频繁,尤其是在搬家后不久被诊断出的病例。当检查儿童出生前一年母亲的居住情况时,这一时期的搬家相对较少(总共26次,即24%,其中14次距离超过5公里,9次来自另一个行政区)。其中,18名病例组母亲搬过家(11次距离超过5公里),而对照组母亲有8名搬过家(3次距离超过5公里)。(摘要截选至250字)