Hellberg D, Zdolsek B, Nilsson S, Mårdh P A
Department of Obstetrics and Gynecology, Falun Hospital, Sweden.
Eur J Epidemiol. 1995 Oct;11(5):575-9. doi: 10.1007/BF01719311.
One hundred and two women with a history of a median of six episodes of vulvovaginal candidiasis (VVC) and 204 age-matched controls participated in a structured in-depth interview on sexual behavior. Mean and median ages of the two groups were 26.7 and 26 years, respectively. Sexual characteristics, associated with VVC in crude analyses, were adjusted in multifactorial analyses for coital frequency, experience of casual sex, vaginal irritation, smoking, alcohol habits, and having a steady partner. In addition, education, as a measure of socioeconomic status, was added in the multifactorial analyses. VVC was not associated with multiple sexual partners or ever-experience of causal sex. Sexual variables that remained significant or were of borderline significance after adjustment were: age at first intercourse (p = 0.001), causal sex partners the previous month (odds ratio (OR) = 3.1), sex during menstruation (OR = 1.7), regular oral sex (OR = 2.4), experience of anal intercourse ever (OR = 2.4), oral intercourse the last month (OR = 3.1), and frequency of oral intercourse (p = 0.02). Thus, the study indicates that certain sexual activities are associated with repeated episodes of VVC.
102名有复发性外阴阴道假丝酵母菌病（VVC）病史（中位数为6次发作）的女性和204名年龄匹配的对照者参与了一项关于性行为的结构化深度访谈。两组的平均年龄和中位数年龄分别为26.7岁和26岁。在粗分析中与VVC相关的性特征，在多因素分析中针对性交频率、一夜情经历、阴道刺激、吸烟、饮酒习惯和有固定伴侣等因素进行了调整。此外，作为社会经济地位衡量指标的教育程度也被纳入多因素分析。VVC与多个性伴侣或一夜情经历无关。调整后仍具有显著意义或临界意义的性变量包括：初次性交年龄（p = 0.001）、前一个月的一夜情性伴侣（比值比（OR）= 3.1）、月经期性交（OR = 1.7）、定期口交（OR = 2.4）、曾有肛交经历（OR = 2.4）、上个月口交（OR = 3.1）以及口交频率（p = 0.02）。因此，该研究表明某些性活动与VVC的反复发作有关。
