Prioleau W H, Alken A F, Hairston P
Ann Surg. 1977 Jun;185(6):678-83. doi: 10.1097/00000658-197706000-00010.
Three hundred seventeen carotid endarterectomies performed on 240 consecutive patients in four Charleston hospitals were reviewed. The overall incidence of stroke was 10.7% and the mortality 3.2%. From these 317 operations a standardized series of 253 operations performed on neurologically stable patients was analyzed for neurologic complications as related to the use of an intra-operative shunt. Additional factors studied were length of time of carotid occlusion and degree of contralateral carotid stenosis. From the standardized series the incidence of stroke in 137 shunted cases was 9.5%, and in 116 non-shunted cases was 0.9%, a significant difference (p less than 0.01). Carotid artery occlusion times from 30 seconds to 12 minutes in the shunted group, and three minutes to 24 minutes in the non-shunted group had no relationship to the incidence of stroke. Significant contralateral carotid artery stenosis, present in 28/137 shunted cases and 30/116 non-shunted cases, had no predictive value in the development of a stroke. The use of an intra-operative shunt did not protect against stroke in these patients.
对查尔斯顿四家医院连续收治的240例患者进行的317例颈动脉内膜切除术进行了回顾。总体卒中发生率为10.7%,死亡率为3.2%。从这317例手术中,选取了253例在神经功能稳定患者身上进行的标准化手术系列,分析与术中分流使用相关的神经并发症。研究的其他因素包括颈动脉阻断时间和对侧颈动脉狭窄程度。在标准化系列中,137例分流病例的卒中发生率为9.5%,116例未分流病例的卒中发生率为0.9%,差异有统计学意义(p<0.01)。分流组颈动脉阻断时间为30秒至12分钟,未分流组为3分钟至24分钟,与卒中发生率无关。137例分流病例中的28例和116例未分流病例中的30例存在明显的对侧颈动脉狭窄,对卒中的发生没有预测价值。在这些患者中,术中使用分流并不能预防卒中。