Haffner S M, Stern M P, Miettinen H, Wei M, Gingerich R L
Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7873, USA.
Diabetes. 1996 Jun;45(6):822-4. doi: 10.2337/diab.45.6.822.
Leptin, the product of the OB gene, is increased in obese individuals, suggesting resistance to its effect. We questioned whether subjects with NIDDM have an altered regulation of serum leptin levels. We used a radioimmunoassay to measure serum leptin levels in three groups from the San Antonio Heart Study: 1) 50 Mexican-Americans with NIDDM; 2) 50 nondiabetic Mexican-Americans matched by age and sex to the diabetic Mexican-Americans; and 3) 50 nondiabetic Mexican-Americans matched by age, sex, and BMI to the diabetic Mexican-Americans. Leptin concentrations did not differ significantly by diabetic status. Leptin concentrations were significantly correlated with BMI in all groups (NIDDM women: r = 0.637; nondiabetic women: r = 0.772; NIDDM men: r = 0.849; and nondiabetic men: r = 0.686; all P < 0.001). Leptin levels were higher in women than in men regardless of diabetic status. We concluded that the leptin concentrations were not different in diabetic and nondiabetic subjects and that the association of leptin with obesity was similar in diabetic and nondiabetic subjects.
瘦素是OB基因的产物，在肥胖个体中含量升高，提示存在对其作用的抵抗。我们质疑非胰岛素依赖型糖尿病（NIDDM）患者的血清瘦素水平调节是否存在改变。我们采用放射免疫分析法，对圣安东尼奥心脏研究中的三组对象测定血清瘦素水平：1）50名患有NIDDM的墨西哥裔美国人；2）50名年龄和性别与患糖尿病的墨西哥裔美国人相匹配的非糖尿病墨西哥裔美国人；3）50名年龄、性别和体重指数（BMI）与患糖尿病的墨西哥裔美国人相匹配的非糖尿病墨西哥裔美国人。瘦素浓度在糖尿病状态方面无显著差异。在所有组中，瘦素浓度均与BMI显著相关（NIDDM女性：r = 0.637；非糖尿病女性：r = 0.772；NIDDM男性：r = 0.849；非糖尿病男性：r = 0.686；均P < 0.001）。无论糖尿病状态如何，女性的瘦素水平均高于男性。我们得出结论，糖尿病患者和非糖尿病患者的瘦素浓度无差异，且糖尿病患者和非糖尿病患者中瘦素与肥胖的关联相似。
