一种非洲猪瘟病毒Bc1-2同源物5-HL可抑制凋亡性细胞死亡。
An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell death.
作者信息
Afonso C L, Neilan J G, Kutish G F, Rock D L
机构信息
Plum Island Animal Disease Center, Agriculture Research Service, U.S. Department of Agriculture, Greenport, New York 11944-0848, USA.
出版信息
J Virol. 1996 Jul;70(7):4858-63. doi: 10.1128/JVI.70.7.4858-4863.1996.
Abstract
Here, we show that the African swine fever virus 5-HL gene is a highly conserved viral gene and contains all known protein domains associated with Bcl-2 activity, including those involved with dimerization, mediating cell death, and protein-binding functions, and that its protein product, p21, suppresses apoptotic cell death in the mammalian lymphoid cell line FL5.12. Thus, 5-HL is a true functional viral member of the Bcl-2 gene family.
摘要
在此，我们表明非洲猪瘟病毒5-HL基因是一个高度保守的病毒基因，包含所有已知的与Bcl-2活性相关的蛋白质结构域，包括那些参与二聚化、介导细胞死亡和蛋白质结合功能的结构域，并且其蛋白质产物p21可抑制哺乳动物淋巴样细胞系FL5.12中的凋亡性细胞死亡。因此，5-HL是Bcl-2基因家族真正具有功能的病毒成员。
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