Kamerling J P, Duran M, Bruinvis L, Ketting D, Wadman S K, de Groot C J, Hommes F A
Clin Chim Acta. 1977 Jun 15;77(3):397-405. doi: 10.1016/0009-8981(77)90246-7.
An unknown acidic compound was detected in a number of urine samples from patients with a suspected metabolic disorder and some patients treated with chemotherapy. The structure of this compound has been characterized as (2-ethoxyethoxy)acetic acid, using a gas chromatography/mass spectrometry/computer system. The authentic compound was synthesized and compared with the unknown. Urinary (2-ethoxyethoxy)acetic acid is assumed to be formed endogenously from an exogenous precursor, probably 2-(2-ethoxyethoxy)ethanol.
在一些疑似患有代谢紊乱的患者以及一些接受化疗的患者的尿液样本中检测到一种未知的酸性化合物。利用气相色谱/质谱/计算机系统,已将该化合物的结构鉴定为(2-乙氧基乙氧基)乙酸。合成了该纯化合物并与未知物进行了比较。尿中的(2-乙氧基乙氧基)乙酸被认为是由一种外源性前体物质内源性形成的,这种前体物质可能是2-(2-乙氧基乙氧基)乙醇。