Clarke M, Schild G C, Boustred J, Seagroatt V, Pollock T M, Finlay S E, Barbara J A
Lancet. 1979 Jun 9;1(8128):1224-6. doi: 10.1016/s0140-6736(79)91906-8.
Antibody to rubella virus was measured in over 10,000 serum samples collected in 1976, 1977, and 1978 from young adult blood donors and university students. The incidence of seronegatives was lower (4--7%) among females born in 1956 and subsequently--i.e., among the age groups offered rubella vaccine at school--than among females born before 1654 (11--20%). The incidence of seronegatives among males in the 1977 and 1978 surveys had the opposite trend, with a higher proportion of seronegatives in younger males, born in 1956 and subsequently, than in older males. The findings provide evidence that the rubella vaccination programme in the U.K. is having a significant impact on the immunological status of young females of childbearing age. Nevertheless too high a proportion of young females remains potentially susceptible to rubella.
对1976年、1977年和1978年从年轻成年献血者和大学生中采集的10000多份血清样本检测了风疹病毒抗体。1956年及以后出生的女性（即在学校接种风疹疫苗的年龄组）中血清阴性的发生率（4%-7%）低于1954年以前出生的女性（11%-20%）。在1977年和1978年的调查中，男性血清阴性的发生率呈现相反趋势，1956年及以后出生的年轻男性中血清阴性的比例高于年长男性。这些发现证明，英国的风疹疫苗接种计划对育龄年轻女性的免疫状况产生了重大影响。然而，仍有过高比例的年轻女性可能易患风疹。
