Horne D, Tomasz A
Antimicrob Agents Chemother. 1977 May;11(5):888-96. doi: 10.1128/AAC.11.5.888.
In contrast to group A streptococci or Streptococcus pneumoniae, cells of Streptococcus sanguis (group H) do not exhibit the irreversible effects of penicillin treatment, such as loss of viability or lysis. On the other hand, the same bacteria show typical effects of penicillin, such as morphological alterations, reduction in the rate of cell wall synthesis, and secretion of murein and lipoteichoic acid polymers into the medium. A novel effect of cell wall inhibitors was also noted: treatment with beta-lactams or with fosfomycin, d-cycloserine, or beta-halogeno-d-alanine caused the release of substantial amounts of glycerol lipids into the growth medium. The antibiotic "tolerance" of S. sanguis is interpreted in terms of the hypothesis that the activity of bacterial murein hydrolases is essential for the irreversible effects of cell wall inhibitors.
与A组链球菌或肺炎链球菌不同，血链球菌（H组）细胞不会表现出青霉素治疗的不可逆效应，如活力丧失或裂解。另一方面，相同的细菌会表现出青霉素的典型效应，如形态改变、细胞壁合成速率降低以及胞壁质和脂磷壁酸聚合物分泌到培养基中。还注意到细胞壁抑制剂的一种新效应：用β-内酰胺类药物、磷霉素、d-环丝氨酸或β-卤代-d-丙氨酸处理会导致大量甘油脂质释放到生长培养基中。血链球菌的抗生素“耐受性”根据细菌胞壁质水解酶的活性对于细胞壁抑制剂的不可逆效应至关重要这一假说来解释。
