Celesia G G, Daly R F
Arch Neurol. 1977 Jul;34(7):403-7. doi: 10.1001/archneur.1977.00500190037005.
The effects of aging of visual evoked responses (VER) and critical frequency of photic driving (CFPD) was studied in 74 volunteers aged 18 to 79. The amplitude of VER to pattern reversal stimulation did not vary with sex or age. The latencies of the first major negative and of the first major positive defection of the VER were significantly delayed (P less than .001) with advancing age. This increase of latency probably reflects a slowing of conduction velocity in the optic nerve or optic pathways or both. CFPD, defined as the highest frequency of photic driving response expressed in flashes per second, showed an inverse correlation, decreasing with age in older subjects. Critical frequency of photic driving is the electrophysiological counterpart of critical flicker fusion, which is known to decrease with advancing age. These data support the concept that aging influences the functions of specialized sensory systems.
对74名年龄在18至79岁之间的志愿者进行了视觉诱发电位（VER）老化效应和闪光刺激临界频率（CFPD）的研究。模式反转刺激下VER的振幅不随性别或年龄而变化。随着年龄的增长，VER首次主要负向波和首次主要正向波的潜伏期显著延迟（P小于0.001）。潜伏期的这种增加可能反映了视神经或视路或两者传导速度的减慢。CFPD定义为以每秒闪光次数表示的闪光刺激反应的最高频率，呈负相关，在老年受试者中随年龄增长而降低。闪光刺激临界频率是临界闪烁融合的电生理对应物，已知其会随着年龄的增长而降低。这些数据支持衰老会影响特殊感觉系统功能这一概念。
