来自扇蟹科花纹爱洁蟹的一种新的石房蛤毒素类似物。

A new saxitoxin analogue from a xanthid crab Atergatis floridus.

作者信息

Arakawa O, Nishio S, Noguchi T, Shida Y, Onque Y

机构信息

Faculty of Fisheries, Kagoshima University, Japan.

出版信息

Toxicon. 1995 Dec;33(12):1577-84. doi: 10.1016/0041-0101(95)00106-9.

DOI:10.1016/0041-0101(95)00106-9

PMID:8866615

Abstract

A novel paralytic toxin was isolated from toxic specimens of a xanthid crab Atergatis floridus inhabiting the Pacific coast of Shikoku Island. Its structure was deduced to be 11-saxitoxinethanoic acid (SEA) based on high-performance liquid chromatography, electrospray ionization mass spectrometry, and 1H and 13C-NMR spectrometries. This acid was assumed to exist as an equilibrium mixture of three tautomers, the main tautomer being the hydrate form 11 beta-epimer. SEA showed a specific toxicity of 830 mouse units per mumole on i.p. injection into mice.

摘要

从栖息于四国岛太平洋沿岸的扇蟹属剧毒标本中分离出一种新型麻痹毒素。基于高效液相色谱、电喷雾电离质谱以及1H和13C核磁共振光谱分析，推断其结构为11-石房蛤毒素乙酸（SEA）。该酸被认为是以三种互变异构体的平衡混合物形式存在，主要互变异构体为水合物形式的11β-差向异构体。将SEA腹腔注射到小鼠体内时，其比毒性为每微摩尔830小鼠单位。