体外诱导人抗原特异性和非特异性辅助因子
Induction of human antigen-specific and non-specific helper factors in vitro.
作者信息
Kantor F, Feldmann M
出版信息
Clin Exp Immunol. 1979 Apr;36(1):71-7.
Abstract
Human peripheral blood leucocytes, cultured for 4--6 days with the appropriate concentration of protein or synthetic polypeptide antigen, yield helper cells. These cells, after a further 24 hr incubation with the appropriate antigen release helper factors, which are of two types, antigen specific and non-specific; a similar situation to that described in the mouse. These factors are assayed by their effects on the plaque-forming cell response of mouse spleen cells cultures in vitro. The potential applications of this new assay for human T cell function are discussed.
摘要
人外周血白细胞在适当浓度的蛋白质或合成多肽抗原中培养4 - 6天，可产生辅助细胞。这些细胞在与适当抗原进一步孵育24小时后释放辅助因子，辅助因子有两种类型，即抗原特异性和非特异性；这与小鼠中描述的情况类似。这些因子通过其对体外培养的小鼠脾细胞空斑形成细胞反应的影响来测定。本文讨论了这种用于人类T细胞功能的新检测方法的潜在应用。
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Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
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Cell interactions in the immune response in vitro. 3. Specific collaboration across a cell impermeable membrane.体外免疫反应中的细胞相互作用。3. 跨细胞不可渗透膜的特异性协作。
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Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. I. Characterization of the inhibitory cell activity.伴刀豆球蛋白A对小鼠脾细胞悬液对抗原反应的抑制和刺激作用。I. 抑制性细胞活性的特性
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