Shimokawa I, Higami Y, Yu B P, Masoro E J, Ikeda T
Department of Pathology, Nagasaki University School of Medicine, Japan.
Aging (Milano). 1996 Aug;8(4):254-62. doi: 10.1007/BF03339576.
The influence of dietary components on the occurrence of, and mortality from spontaneous neoplasms in male F344 rats was investigated. The dietary regimens studied included restriction of specific dietary components (energy, fat, protein and mineral), as well as different sources of dietary protein (casein, soy protein and lactalbumin). A statistical approach based on contributing causes of death was used to obtain the mortality due to all neoplasms, and the relative onset rate of frequently observed neoplasms, e.g., leukemia, pituitary adenoma, testicular interstitial cell tumor, etc. Only the regimen involving energy restriction reduced the mortality due to all neoplasms. Neither reduction of individual components without energy restriction, nor replacement of casein with soy protein or lactalbumin as the protein source affected mortality. Analyses of the relative onset rate of selected neoplasms also indicated that only a reduction of energy intake suppressed the occurrence of most of these neoplasms. Other dietary regimens, at most, suppressed a few types of neoplasm. It is concluded that a reduction in energy intake is a key dietary factor for the prevention of neoplastic diseases in rats.
研究了膳食成分对雄性F344大鼠自发性肿瘤发生及死亡率的影响。所研究的饮食方案包括限制特定膳食成分（能量、脂肪、蛋白质和矿物质），以及不同来源的膳食蛋白质（酪蛋白、大豆蛋白和乳白蛋白）。采用基于死亡原因的统计方法来获取所有肿瘤导致的死亡率，以及常见肿瘤（如白血病、垂体腺瘤、睾丸间质细胞瘤等）的相对发病几率。只有能量限制方案降低了所有肿瘤导致的死亡率。在不限制能量的情况下，单独减少个别成分，或用大豆蛋白或乳白蛋白替代酪蛋白作为蛋白质来源，均未影响死亡率。对选定肿瘤相对发病几率的分析还表明，只有减少能量摄入才能抑制大多数此类肿瘤的发生。其他饮食方案最多只能抑制少数几种肿瘤。得出的结论是，减少能量摄入是预防大鼠肿瘤性疾病的关键饮食因素。
