非裔美国人可能不参与临床试验的原因。
Why African Americans may not be participating in clinical trials.
作者信息
Harris Y, Gorelick P B, Samuels P, Bempong I
机构信息
Center on Stroke Research, Rush Medical Center, University of Illinois at Chicago, 60612, USA.
出版信息
J Natl Med Assoc. 1996 Oct;88(10):630-4.
Abstract
African Americans have been underrepresented in clinical trials. This study was designed to determine factors that may help explain the low participation rate of African Americans in clinical trials. A historical review documented past medical experimentation and other practices on blacks that were often brutal and unethical. These experiences may have served to fortify the legacy of African-American mistrust in the medical system and culminated in the infamous Tuskegee Syphilis Study. Four major barriers to participation in clinical trials were identified: lack of awareness about trials, economic factors, communication issues, and mistrust. These barriers, as well as others, can be surmounted with proper pretrial planning, patient education, genuine commitment and concern by study staff, and hard work to overcome deficiencies.
摘要
非裔美国人在临床试验中的代表性一直不足。本研究旨在确定可能有助于解释非裔美国人参与临床试验率低的因素。一项历史回顾记录了过去针对黑人的医学实验和其他往往残忍且不道德的做法。这些经历可能强化了非裔美国人对医疗系统不信任的传统，并最终导致了臭名昭著的塔斯基吉梅毒研究。确定了参与临床试验的四大障碍：对试验缺乏认识、经济因素、沟通问题和不信任。通过适当的试验前规划、患者教育、研究人员的真诚投入和关心以及努力克服缺陷，这些障碍以及其他障碍是可以克服的。
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