乳酸菌可诱导人体产生肿瘤坏死因子α、白细胞介素-6和白细胞介素-10。
Production of human tumor necrosis factor alpha, interleukin-6, and interleukin-10 is induced by lactic acid bacteria.
作者信息
Miettinen M, Vuopio-Varkila J, Varkila K
机构信息
National Public Health Institute, Helsinki, Finland.
出版信息
Infect Immun. 1996 Dec;64(12):5403-5. doi: 10.1128/iai.64.12.5403-5405.1996.
Abstract
To investigate the role of cytokines in interactions between lactic acid bacteria and the immune system, we measured production of tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-10 from human peripheral blood mononuclear cells after stimulation with live or glutaraldehyde-fixed bacteria. Production of tumor necrosis factor alpha, IL-6, and, in some cases, IL-10 was induced in amounts even greater than those obtained with lipopolysaccharide as a stimulant. Our results suggest that lactic acid bacteria can stimulate nonspecific immunity.
摘要
为研究细胞因子在乳酸菌与免疫系统相互作用中的作用，我们检测了用活的或经戊二醛固定的细菌刺激后人外周血单核细胞中肿瘤坏死因子α、白细胞介素-6（IL-6）和IL-10的产生情况。肿瘤坏死因子α、IL-6以及在某些情况下IL-10的产生量甚至比用脂多糖作为刺激物时还要高。我们的结果表明乳酸菌可刺激非特异性免疫。
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