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Facial palsy, meningococcal meningitis, and reactivation of herpes simplex virus.面神经麻痹、脑膜炎球菌性脑膜炎和单纯疱疹病毒再激活。
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Serum-induced potentiation of tumor necrosis factor alpha production by human monocytes in response to staphylococcal peptidoglycan: involvement of different serum factors.血清诱导人单核细胞对葡萄球菌肽聚糖产生肿瘤坏死因子α的增强作用：不同血清因子的参与
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Induction of tumor necrosis factor alpha by the group- and type-specific polysaccharides from type III group B streptococci.B族链球菌III型的群特异性和型特异性多糖对肿瘤坏死因子α的诱导作用。
Infect Immun. 1994 Jul;62(7):2748-53. doi: 10.1128/iai.62.7.2748-2753.1994.
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乳酸菌可诱导人体产生肿瘤坏死因子α、白细胞介素-6和白细胞介素-10。

Production of human tumor necrosis factor alpha, interleukin-6, and interleukin-10 is induced by lactic acid bacteria.

作者信息

Miettinen M, Vuopio-Varkila J, Varkila K

机构信息

National Public Health Institute, Helsinki, Finland.

出版信息

Infect Immun. 1996 Dec;64(12):5403-5. doi: 10.1128/iai.64.12.5403-5405.1996.

DOI:10.1128/iai.64.12.5403-5405.1996
PMID:8945595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174537/
Abstract

To investigate the role of cytokines in interactions between lactic acid bacteria and the immune system, we measured production of tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-10 from human peripheral blood mononuclear cells after stimulation with live or glutaraldehyde-fixed bacteria. Production of tumor necrosis factor alpha, IL-6, and, in some cases, IL-10 was induced in amounts even greater than those obtained with lipopolysaccharide as a stimulant. Our results suggest that lactic acid bacteria can stimulate nonspecific immunity.

摘要

为研究细胞因子在乳酸菌与免疫系统相互作用中的作用，我们检测了用活的或经戊二醛固定的细菌刺激后人外周血单核细胞中肿瘤坏死因子α、白细胞介素-6（IL-6）和IL-10的产生情况。肿瘤坏死因子α、IL-6以及在某些情况下IL-10的产生量甚至比用脂多糖作为刺激物时还要高。我们的结果表明乳酸菌可刺激非特异性免疫。