Department of Food Gastronomy and Food Hygiene, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 159C Str., (Building No. 32), 02-776 Warsaw, Poland.
Neurocognitive Research Center, SWPS University of Social Sciences and Humanities, Chodakowska Str. 19/31, 03-815 Warsaw, Poland.
Int J Environ Res Public Health. 2022 Sep 3;19(17):11022. doi: 10.3390/ijerph191711022.
Psychobiotics are defined as probiotics, mainly of the genus and , that confer mental health benefits to the host when consumed in a particular quantity through the interaction with commensal gut microbiota. The gut microbiota, which means a diverse and dynamic population of microorganisms harboring the gastrointestinal tract, communicates with the brain and vice versa through the brain-gut axis. The mechanisms of action of psychobiotics may be divided into four groups: synthesis of neurotransmitters and neurochemicals, regulation of the HPA axis, influence on the immune system, and synthesis of metabolites. Recent years showed that the COVID-19 pandemic affected not only physical, but also mental health. Social isolation, fear of infection, the lack of adequate vaccine, disinformation, increased number of deaths, financial loss, quarantine, and lockdown are all factors can cause psychiatric problems. The aim of this review was to discuss the potential role of psychobiotic in light of the current problems, based on and studies, meta-analyses, clinical trials evidence, and registered studies assessing probiotics' therapeutic administration in the prevention or treatment of symptoms or side effects of COVID-19.
益生菌被定义为益生菌，主要来自属 和 ，当以特定数量通过与共生肠道微生物群的相互作用被宿主消耗时，赋予宿主心理健康益处。肠道微生物群是指栖息在胃肠道中的具有多样性和动态性的微生物种群，通过脑-肠轴与大脑进行交流，反之亦然。益生菌的作用机制可分为四组：神经递质和神经化学物质的合成、HPA 轴的调节、对免疫系统的影响以及代谢物的合成。近年来的研究表明，COVID-19 大流行不仅影响了身体，还影响了心理健康。社会隔离、对感染的恐惧、缺乏足够的疫苗、虚假信息、死亡人数增加、经济损失、隔离和封锁都是可能导致精神问题的因素。本综述旨在根据 和 研究、荟萃分析、临床试验证据以及评估益生菌治疗 COVID-19 症状或副作用的预防或治疗的注册研究，讨论在当前问题背景下益生菌的潜在作用。
