Doumas B T, Peters T
Medical College of Wisconsin, Department of Pathology, Milwaukee 53226-0509, USA.
Clin Chim Acta. 1997 Feb 3;258(1):3-20. doi: 10.1016/s0009-8981(96)06446-7.
For about 25 years, bromcresol green and bromcresol purple have been the basis for most of the measurements of serum albumin in the US and perhaps in the world. The longevity of the methods is due to their being simple, sensitive, specific, inexpensive and relatively free from interferences. The lack of change in the serum albumin methodology is balanced by two important developments. First, the recognition of the importance of serum albumin in the maintenance of good health, and the association of decreased concentrations with increased risk of morbidity and mortality. Second, the association of albuminuria with diabetic nephropathy, which without medical intervention could lead to end-stage renal disease. The development of accurate and precise methods for urinary albumin has provided a tool to physicians to extend the length and improve the quality of life of many diabetic individuals.
大约25年来，溴甲酚绿和溴甲酚紫一直是美国乃至世界上大多数血清白蛋白测量方法的基础。这些方法经久不衰是因为它们简单、灵敏、特异、廉价且相对不受干扰。血清白蛋白检测方法缺乏变化的情况因两项重要进展而得到平衡。第一，认识到血清白蛋白在维持健康方面的重要性，以及浓度降低与发病和死亡风险增加之间的关联。第二，蛋白尿与糖尿病肾病的关联，若无医学干预，可能会导致终末期肾病。准确精密的尿白蛋白检测方法的发展为医生提供了一种工具，可延长许多糖尿病患者的寿命并提高其生活质量。
