Wu A W, Jacobson D L, Berzon R A, Revicki D A, van der Horst C, Fichtenbaum C J, Saag M S, Lynn L, Hardy D, Feinberg J
School of Hygiene and Public Health, Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD, USA.
Qual Life Res. 1997 Jan;6(1):3-10. doi: 10.1023/a:1026471020698.
Brief measures of health-related quality of life are being used with increased frequency in AIDS clinical trials. Self-administration of questionnaires can reduce costs in this setting because they require little time. However, the equivalence between self- and interview-administered responses in clinical trials is not known. We evaluated patient and proxy responses to the Medical Outcomes Study HIV Health Survey (MOS-HIV) and the EuroQol. We randomized 68 patients with advanced HIV disease on (1) mode of administration (self vs. interview); (2) type of interview (face-to-face vs. telephone); (3) questionnaire order (MOS-first vs. EuroQol-first); and (4) 2- vs. 3-item response categories for physical limitations. There were few differences in scores between self and interview administration and type of interview. Proxy respondents viewed patients as more impaired than did patients themselves on subjective aspects of health including mental health (63.8 vs. 75.7, p < 0.001), health distress (67.3 vs. 77.1, p = 0.007), pain (64.4 vs. 70.0, p = 0.04), and vitality (48.4 vs. 55.5, p = 0.04). Results concerning questionnaire order and number of response categories were not conclusive. Our results suggest that for patients with advanced HIV disease, data from the MOS-HIV and the EuroQol collected using different modes may be pooled, but that proxy responses should be calibrated.
在艾滋病临床试验中，与健康相关的生活质量简短测量方法的使用频率越来越高。在这种情况下，问卷的自我管理可以降低成本，因为它们所需时间很少。然而，临床试验中自我管理和访谈管理的回答之间的等效性尚不清楚。我们评估了患者及其代理人对医学结局研究艾滋病毒健康调查（MOS-HIV）和欧洲生活质量五维度问卷（EuroQol）的回答。我们将68例晚期艾滋病毒疾病患者随机分为：（1）管理方式（自我管理与访谈管理）；（2）访谈类型（面对面访谈与电话访谈）；（3）问卷顺序（先填MOS-HIV问卷与先填EuroQol问卷）；以及（4）身体功能受限的2项与3项回答类别。自我管理和访谈管理以及访谈类型之间的得分差异很小。在包括心理健康（63.8对75.7，p<0.001）、健康困扰（67.3对77.1，p = 0.007）、疼痛（64.4对70.0，p = 0.04）和活力（48.4对55.5，p = 0.04）在内的健康主观方面，代理人受访者认为患者的受损程度比患者自己认为的更严重。关于问卷顺序和回答类别数量的结果尚无定论。我们的结果表明，对于晚期艾滋病毒疾病患者，使用不同方式收集的MOS-HIV和EuroQol数据可以合并，但代理人的回答应进行校准。
