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本文引用的文献

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Antifungal drug susceptibilities of oral Candida dubliniensis isolates from human immunodeficiency virus (HIV)-infected and non-HIV-infected subjects and generation of stable fluconazole-resistant derivatives in vitro.来自人类免疫缺陷病毒（HIV）感染和未感染HIV受试者的口腔都柏林念珠菌分离株的抗真菌药敏性及体外稳定氟康唑耐药衍生物的产生
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Molecular genetic approaches to identification, epidemiology and taxonomy of non-albicans Candida species.用于非白色念珠菌属念珠菌鉴定、流行病学研究及分类学的分子遗传学方法。
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Oral Candida in HIV infection and AIDS: new perspectives/new approaches.HIV感染与艾滋病中的口腔念珠菌：新观点/新方法
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Oligonucleotide fingerprinting of isolates of Candida species other than C. albicans and of atypical Candida species from human immunodeficiency virus-positive and AIDS patients.对来自人类免疫缺陷病毒阳性患者和艾滋病患者的白色念珠菌以外的念珠菌属分离株及非典型念珠菌属进行寡核苷酸指纹分析。
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Genotype and phenotype of oral Candida albicans from patients infected with the human immunodeficiency virus.感染人类免疫缺陷病毒患者口腔白色念珠菌的基因型和表型
Microbiology (Reading). 1994 May;140 ( Pt 5):1195-202. doi: 10.1099/13500872-140-5-1195.
6
CHROMagar Candida, a new differential isolation medium for presumptive identification of clinically important Candida species.科玛嘉念珠菌显色培养基，一种用于初步鉴定临床重要念珠菌属菌种的新型鉴别分离培养基。
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Characterization of genetically distinct subgroup of Candida albicans strains isolated from oral cavities of patients infected with human immunodeficiency virus.从感染人类免疫缺陷病毒患者口腔分离出的白色念珠菌菌株基因不同亚组的特征分析
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8
Cluster of oral atypical Candida albicans isolates in a group of human immunodeficiency virus-positive drug users.一组人类免疫缺陷病毒阳性吸毒者中口腔非典型白色念珠菌分离株的聚集情况。
J Clin Microbiol. 1995 May;33(5):1129-35. doi: 10.1128/jcm.33.5.1129-1135.1995.
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Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals.新型都柏林念珠菌：与HIV感染者口腔念珠菌病相关的新物种的表型和分子特征
Microbiology (Reading). 1995 Jul;141 ( Pt 7):1507-21. doi: 10.1099/13500872-141-7-1507.
10
A Candida albicans dispersed, repeated gene family and its epidemiologic applications.白色念珠菌的一个分散的重复基因家族及其流行病学应用。
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人类免疫缺陷病毒感染个体中口腔都柏林念珠菌菌株的广泛地理分布。

Widespread geographic distribution of oral Candida dubliniensis strains in human immunodeficiency virus-infected individuals.

作者信息

Sullivan D, Haynes K, Bille J, Boerlin P, Rodero L, Lloyd S, Henman M, Coleman D

机构信息

Department of Oral Medicine and Pathology, School of Dental Science, Trinity College, University of Dublin, Republic of Ireland.

出版信息

J Clin Microbiol. 1997 Apr;35(4):960-4. doi: 10.1128/jcm.35.4.960-964.1997.

DOI:10.1128/jcm.35.4.960-964.1997
PMID:9157162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC229710/
Abstract

Candida dubliniensis is a recently identified chlamydospore-positive yeast species associated with oral candidiasis in human immunodeficiency virus (HIV)-infected (HIV+) patients and is closely related to Candida albicans. Several recent reports have described atypical oral Candida isolates with phenotypic and genetic properties similar to those of C. dubliniensis. In this study 10 atypical chlamydospore-positive oral isolates from HIV+ patients in Switzerland, the United Kingdom, and Argentina and 1 isolate from an HIV-negative Irish subject were compared to reference strains of C. albicans and Candida stellatoidea and reference strains of C. dubliniensis recovered from Irish and Australian HIV+ individuals. All 11 isolates were phenotypically and genetically similar to and phylogenetically identical to C. dubliniensis. These findings demonstrate that the geographical distribution of C. dubliniensis is widespread, and it is likely that it is a significant constituent of the normal oral flora with the potential to cause oral candidiasis, particularly in immunocompromised patients.

摘要

都柏林念珠菌是一种最近才被鉴定出来的、产生厚垣孢子的酵母菌种，与人类免疫缺陷病毒（HIV）感染（HIV+）患者的口腔念珠菌病有关，并且与白色念珠菌密切相关。最近的几份报告描述了一些非典型口腔念珠菌分离株，它们具有与都柏林念珠菌相似的表型和遗传特性。在本研究中，将来自瑞士、英国和阿根廷的10株HIV+患者的非典型厚垣孢子阳性口腔分离株以及1株来自HIV阴性爱尔兰受试者的分离株，与白色念珠菌和星状念珠菌的参考菌株以及从爱尔兰和澳大利亚HIV+个体中分离出的都柏林念珠菌参考菌株进行了比较。所有11株分离株在表型和遗传上均与都柏林念珠菌相似，并且在系统发育上与之一致。这些发现表明，都柏林念珠菌的地理分布广泛，并且它很可能是正常口腔菌群的重要组成部分，有可能导致口腔念珠菌病，尤其是在免疫功能低下的患者中。