Ross G H
Environmental Health Center-Dallas, Texas 75231, USA.
Environ Health Perspect. 1997 Mar;105 Suppl 2(Suppl 2):437-41. doi: 10.1289/ehp.97105s2437.
A case history of the induction of asthma and chemical sensitivity in a 42-year-old registered nurse illustrates several of the characteristic features of multiple chemical sensitivity (MCS). This patient's problems started shortly after moving into a new home under construction, with associated chemical exposures. Other MCS patients report the onset of the condition with other chemical exposures such as those encountered at their places of work or use of pesticides at their residences. Patients often describe a spreading phenomenon of increasing intolerance to commonly encountered chemicals at concentrations well tolerated by other people. Symptoms usually wax and wane with exposures, and are more likely to occur in patients or families with preexisting histories of migraine or with classical allergies. Idiosyncratic medication reactions (especially to preservative chemicals) are common in MCS patients, as are dysautonomia symptoms (such as vascular instability) and poor temperature regulation. Myalgia and joint pains and food intolerance are common features as well. Contamination with xenobiotic chemicals is frequently found in these patients when they are tested. Reactive airways dysfunction syndrome is a recently identified condition that exhibits features of both asthma and chemical sensitivity. MCS patients frequently have patterns of neurotoxic brain metabolism that can be confirmed on single photo emission computed tomography imaging.
一名42岁注册护士患哮喘及化学物质敏感症的病例史，说明了多重化学物质敏感症（MCS）的几个典型特征。该患者的问题在搬进一处正在施工的新家并接触相关化学物质后不久就开始了。其他MCS患者报告称，该病的发作与其他化学物质接触有关，比如在工作场所接触到的化学物质，或在住所使用杀虫剂。患者常描述一种扩散现象，即对其他人能耐受的常见化学物质浓度，他们的不耐受性却在增加。症状通常随接触情况而时起时伏，且更易发生在有偏头痛既往史或典型过敏史的患者或其家族中。MCS患者中，特异质性药物反应（尤其是对防腐剂化学物质的反应）很常见，自主神经功能障碍症状（如血管不稳定）和体温调节不良也很常见。肌痛、关节疼痛和食物不耐受也是常见特征。对这些患者进行检测时，经常发现他们受到外源性化学物质污染。反应性气道功能障碍综合征是一种最近确认的病症，兼具哮喘和化学物质敏感症的特征。MCS患者常有神经毒性脑代谢模式，这可通过单光子发射计算机断层扫描成像得到证实。
