Peana A T, Moretti M D, Manconi V, Desole G, Pippia P
Dipartimento di Scienze del Farmaco, Università di Sassari, Italy.
Planta Med. 1997 Jun;63(3):199-202. doi: 10.1055/s-2006-957652.
Lyophilized aqueous extracts obtained from Agave americana L (Agavaceae) collected in the north of Sardinia were characterized with regard to their steroidal sapogenin content. Extracts of A. americana and genins isolated from them were evaluated for anti-inflammatory properties by testing their effects on carrageenin-induced edema. The effect of orally administered genins on gastric mucous membranes was also assessed. Lyophilized extracts administered by the intraperitoneal route at doses equivalent to 200 and 300 mg/kg of fresh plant starting material, showed good anti-inflammatory activity. Doses of genins (total steroidal sapogenins, hecogenin and tigogenin) equivalent to the amount in the lyophilized extracts produced an antiedentatous effect which was much stronger and more efficacious than that obtained with an i.p. administration of 5 mg/kg of indomethacin or dexamethasone 21-phosphate at a dose equivalent to the molar content of hecogenin administered. At the doses used to evaluate the anti-inflammatory activity, the genins did not have any harmful effect on the gastric mucous membranes. Lesions occurred when significantly higher doses of hecogenin were given, but gastric damage was still less than that caused by the drugs used for comparative purposes.
对从撒丁岛北部采集的龙舌兰（龙舌兰科）冻干水提取物的甾体皂苷元含量进行了表征。通过测试龙舌兰提取物及其分离出的苷元对角叉菜胶诱导的水肿的影响来评估其抗炎特性。还评估了口服苷元对胃黏膜的影响。以相当于200和300mg/kg新鲜植物原料的剂量通过腹腔途径给予冻干提取物，显示出良好的抗炎活性。与冻干提取物中含量相当的苷元剂量（总甾体皂苷元、海柯皂苷元和替告皂苷元）产生的消肿作用比腹腔注射5mg/kg消炎痛或相当于所给药的海柯皂苷元摩尔含量的21-磷酸地塞米松所获得的作用更强且更有效。在用于评估抗炎活性的剂量下，苷元对胃黏膜没有任何有害影响。当给予明显更高剂量的海柯皂苷元时会出现损伤，但胃部损伤仍小于用于比较目的的药物所造成的损伤。
