Shao Y, Ho C T, Chin C K, Poobrasert O, Yang S W, Cordell G A
Department of Plant Science, Cook College, Rutgers, State University of New Jersey, New Brunswich 08903, USA.
J Nat Prod. 1997 Jul;60(7):743-6. doi: 10.1021/np970080t.
A further investigation of Aster lingulatus has led to the isolation of two additional novel triterpene saponins, asterlingulatoside C [3-O-beta-D-glucopyranosyl-3 beta, 16 alpha-dihydroxyolean-12-en-28-oic acid 28-O-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-alpha- L- arabinopyranoside] (1) and asterlingulatoside D [3-O-beta-D-glucopyranosyl-3 beta,16 alpha-dihydroxyolean-12-en-28-oic acid 28-O-beta-D-xylopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-alpha-L- rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside] (2). Elucidation of the structures of 1 and 2 was mainly based on FABMS and 1D and 2D homonuclear and heteronuclear NMR techniques. Compounds 1 and 2 showed good inhibitory activity against DNA synthesis in human leukemia HL-60 cells with IC50 values of 8.8 and 6.1 microM, respectively.
对舌状紫菀的进一步研究已导致分离出另外两种新型三萜皂苷，即舌状紫菀苷C [3-O-β-D-吡喃葡萄糖基-3β,16α-二羟基齐墩果-12-烯-28-酸28-O-β-D-吡喃木糖基-(1→4)-α-L-吡喃鼠李糖基-(1→2)-α-L-阿拉伯吡喃糖苷] (1) 和舌状紫菀苷D [3-O-β-D-吡喃葡萄糖基-3β,16α-二羟基齐墩果-12-烯-28-酸28-O-β-D-吡喃木糖基-(1→3)-β-D-吡喃木糖基-(1→4)-α-L-吡喃鼠李糖基-(1→2)-α-L-阿拉伯吡喃糖苷] (2)。化合物1和2的结构解析主要基于快原子轰击质谱 (FABMS) 以及一维和二维同核和异核核磁共振技术。化合物1和2对人白血病HL-60细胞的DNA合成显示出良好的抑制活性，IC50值分别为8.8和6.1微摩尔。
