冈比亚昏睡病患者的补体激活
Complement activation in patients with Gambian sleeping sickness.
作者信息
Greenwood B M, Whittle H C
出版信息
Clin Exp Immunol. 1976 Apr;24(1):133-8.
Abstract
Low levels of complement components C3, C4 and factor B were found in the sera of most patients with early and advanced Gambian trypanosomiasis. C3 levels increased after treatment with melarsoprol (Mel B). Nearly all patients had high serum IgM levels and a significants correlation was found betwen high serum IgM levels and low serum C3 levels. High concentrations of cryglobulins, which contained IgM and C3, were found in most of sera tested. Formation of large molecular weight IgM complexes may play an important part in producing the low C3 levels found in patients with Gambian sleeping sickness.
摘要
在大多数早期和晚期冈比亚锥虫病患者的血清中发现补体成分C3、C4和B因子水平较低。用美拉胂醇（Mel B）治疗后C3水平升高。几乎所有患者血清IgM水平都很高，并且发现血清高IgM水平与低血清C3水平之间存在显著相关性。在大多数检测的血清中发现了含有IgM和C3的高浓度冷球蛋白。大分子量IgM复合物的形成可能在导致冈比亚昏睡病患者出现低C3水平方面起重要作用。
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