Rubenstein L M, Voelker M D, Chrischilles E A, Glenn D C, Wallace R B, Rodnitzky R L
Department of Preventive Medicine and Environmental Health, University of Iowa, Iowa City 52242, USA.
Qual Life Res. 1998 May;7(4):279-90. doi: 10.1023/a:1024973611880.
Parkinson's disease (PD) has no cure and is a progressive neurological disorder with treatment aimed at the maintenance of function and limitation of the symptoms. No extensive studies of the disease's impact on health-related quality of life (HRQoL) have been conducted. The purpose of this study was to assess the potential usefulness of the Medical Outcomes Study Short Form (SF-36) and the Functional Status Questionnaire (FSQ) in Parkinson's disease research. This cross-sectional study of 193 PD patients who visited two hospital-based neurology clinics used self-administered in-clinic and take-home questionnaires to ascertain the demographic and environmental characteristics of the subjects and to gain health profile measures from the SF-36 and the FSQ. The two health profiles provide important HRQoL information supplementary to the traditional signs and symptoms evaluated by the Unified Parkinson's Disease Rating Scale (UPDRS). Many of the HRQoL measures discriminate progressive stages of disease in this study group and distinguish those with complications of therapy from subjects without complications.
帕金森病（PD）无法治愈，是一种进行性神经疾病，治疗旨在维持功能并限制症状。尚未对该疾病对健康相关生活质量（HRQoL）的影响进行广泛研究。本研究的目的是评估医学结果研究简表（SF - 36）和功能状态问卷（FSQ）在帕金森病研究中的潜在效用。这项横断面研究对193名前往两家医院神经内科诊所就诊的帕金森病患者进行，使用在诊所自行填写和带回家填写的问卷来确定受试者的人口统计学和环境特征，并从SF - 36和FSQ中获取健康状况指标。这两种健康状况指标提供了重要的HRQoL信息，补充了由统一帕金森病评定量表（UPDRS）评估的传统体征和症状。在该研究组中，许多HRQoL指标能够区分疾病的进展阶段，并区分有治疗并发症的患者和无并发症的患者。
