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天然多耐药性质粒整合子中6'-N-氨基糖苷乙酰转移酶基因aac(6')-Iq的特性分析

Characterization of the 6'-N-aminoglycoside acetyltransferase gene aac(6')-Iq from the integron of a natural multiresistance plasmid.

作者信息

Centrón D, Roy P H

机构信息

Département de Biochimie, Faculté des Sciences et de Génie, Université Laval, Sainte-Foy, Québec, Canada.

出版信息

Antimicrob Agents Chemother. 1998 Jun;42(6):1506-8. doi: 10.1128/AAC.42.6.1506.

DOI:10.1128/AAC.42.6.1506
PMID:9624504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105632/
Abstract

The nucleotide sequence of a newly identified amikacin resistance gene, aac(6')-Iq (551 bp), is reported. It has 68.4 and 94.4% homology with the aac(6')-Ia gene and the recently described aac(6')-Ip gene, respectively. Analysis of its flanking sequences indicated that it is in the first cassette of a class I integron and has an attC site (59-base element) 108 bp in length.

摘要

报道了一个新鉴定的阿米卡星抗性基因aac(6')-Iq（551 bp）的核苷酸序列。它与aac(6')-Ia基因及最近描述的aac(6')-Ip基因分别具有68.4%和94.4%的同源性。对其侧翼序列的分析表明，它位于I类整合子的第一个盒式结构中，并且具有一个长度为108 bp的attC位点（59碱基元件）。

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本文引用的文献

1
The emergence of resistance to amikacin in Serratia marcescens isolates from patients with nosocomial infection.耐阿米卡星粘质沙雷氏菌分离株的出现与医院感染患者。
Int J Antimicrob Agents. 1996 Aug;7(3):203-10. doi: 10.1016/s0924-8579(96)00322-6.
2
Characterization of the 6'-N-aminoglycoside acetyltransferase gene aac(6')-Im [corrected] associated with a sulI-type integron.与I类整合子相关的6'-N-氨基糖苷乙酰转移酶基因aac(6')-Im [已校正] 的特性分析
Antimicrob Agents Chemother. 1997 Feb;41(2):314-8. doi: 10.1128/AAC.41.2.314.
3
Gene cassettes: a new class of mobile element.基因盒：一类新型可移动元件。
Microbiology (Reading). 1995 Dec;141 ( Pt 12):3015-27. doi: 10.1099/13500872-141-12-3015.
4
Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.氨基糖苷类耐药基因的分子遗传学及氨基糖苷类修饰酶的家族关系。
Microbiol Rev. 1993 Mar;57(1):138-63. doi: 10.1128/mr.57.1.138-163.1993.
5
Genetic organization of antibiotic resistance genes (aac(6')-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331.多重耐药转座子Tn1331中抗生素抗性基因（aac(6')-Ib、aadA和oxa9）的基因组织
Plasmid. 1993 Jan;29(1):31-40. doi: 10.1006/plas.1993.1004.
6
Characterization of the chromosomal aac(6')-Ii gene specific for Enterococcus faecium.粪肠球菌特异性染色体aac(6')-Ii基因的特征分析。
Antimicrob Agents Chemother. 1993 Sep;37(9):1896-903. doi: 10.1128/AAC.37.9.1896.
7
Diversity and relative strength of tandem promoters for the antibiotic-resistance genes of several integrons.几种整合子抗生素抗性基因串联启动子的多样性和相对强度。
Gene. 1994 May 3;142(1):49-54. doi: 10.1016/0378-1119(94)90353-0.
8
Characterisation of specific and secondary recombination sites recognised by the integron DNA integrase.整合子DNA整合酶识别的特异性和次级重组位点的表征
Nucleic Acids Res. 1994 Jun 11;22(11):2071-8. doi: 10.1093/nar/22.11.2071.
9
PCR mapping of integrons reveals several novel combinations of resistance genes.整合子的聚合酶链反应图谱揭示了几种新型耐药基因组合。
Antimicrob Agents Chemother. 1995 Jan;39(1):185-91. doi: 10.1128/AAC.39.1.185.
10
Cloning and sequencing of a gene encoding an aminoglycoside 6'-N-acetyltransferase from an R factor of Citrobacter diversus.从奇异柠檬酸杆菌的R因子中克隆和测序编码氨基糖苷6'-N-乙酰基转移酶的基因。
J Bacteriol. 1988 Jan;170(1):471-3. doi: 10.1128/jb.170.1.471-473.1988.