天然多耐药性质粒整合子中6'-N-氨基糖苷乙酰转移酶基因aac(6')-Iq的特性分析
Characterization of the 6'-N-aminoglycoside acetyltransferase gene aac(6')-Iq from the integron of a natural multiresistance plasmid.
作者信息
Centrón D, Roy P H
机构信息
Département de Biochimie, Faculté des Sciences et de Génie, Université Laval, Sainte-Foy, Québec, Canada.
出版信息
Antimicrob Agents Chemother. 1998 Jun;42(6):1506-8. doi: 10.1128/AAC.42.6.1506.
Abstract
The nucleotide sequence of a newly identified amikacin resistance gene, aac(6')-Iq (551 bp), is reported. It has 68.4 and 94.4% homology with the aac(6')-Ia gene and the recently described aac(6')-Ip gene, respectively. Analysis of its flanking sequences indicated that it is in the first cassette of a class I integron and has an attC site (59-base element) 108 bp in length.
摘要
报道了一个新鉴定的阿米卡星抗性基因aac(6')-Iq（551 bp）的核苷酸序列。它与aac(6')-Ia基因及最近描述的aac(6')-Ip基因分别具有68.4%和94.4%的同源性。对其侧翼序列的分析表明，它位于I类整合子的第一个盒式结构中，并且具有一个长度为108 bp的attC位点（59碱基元件）。
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