• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Two-component signal transduction as a target for microbial anti-infective therapy.

作者信息

Barrett J F, Hoch J A

机构信息

Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.

出版信息

Antimicrob Agents Chemother. 1998 Jul;42(7):1529-36. doi: 10.1128/AAC.42.7.1529.

DOI:10.1128/AAC.42.7.1529
PMID:9660978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105640/
Abstract
摘要

相似文献

1
Two-component signal transduction as a target for microbial anti-infective therapy.双组分信号转导作为微生物抗感染治疗的靶点。
Antimicrob Agents Chemother. 1998 Jul;42(7):1529-36. doi: 10.1128/AAC.42.7.1529.
2
Bacterial signaling as an antimicrobial target.细菌信号转导作为一种抗菌靶点。
Curr Opin Microbiol. 2020 Oct;57:78-86. doi: 10.1016/j.mib.2020.08.001. Epub 2020 Sep 8.
3
Two-component signal transduction as potential drug targets in pathogenic bacteria.双组分信号转导系统作为病原菌药物靶点的研究进展
Curr Opin Microbiol. 2010 Apr;13(2):232-9. doi: 10.1016/j.mib.2010.01.008. Epub 2010 Feb 4.
4
[Interactions between bacteria and antimicrobials during the postantibiotic effect phase].[抗生素后效应阶段细菌与抗菌药物之间的相互作用]
Rev Esp Quimioter. 1999 Dec;12(4):294-9.
5
Who or what is the source of antibiotic resistance?抗生素耐药性的源头是谁或是什么？
J Med Microbiol. 1997 Jun;46(6):461-4.
6
New trends in antimicrobial development.抗菌药物研发的新趋势
Curr Med Chem. 1998 Apr;5(2):101-13.
7
Inhibitors targeting two-component signal transduction.靶向双组分信号转导的抑制剂。
Adv Exp Med Biol. 2008;631:229-36. doi: 10.1007/978-0-387-78885-2_16.
8
Antibiotic resistance in bacteria.细菌中的抗生素耐药性。
J Med Microbiol. 1992 Jan;36(1):4-29. doi: 10.1099/00222615-36-1-4.
9
Two-component and phosphorelay signal-transduction systems as therapeutic targets.双组分及磷酸化信号转导系统作为治疗靶点。
Curr Opin Pharmacol. 2002 Oct;2(5):507-12. doi: 10.1016/s1471-4892(02)00194-7.
10
Anti-virulence strategies to combat bacteria-mediated disease.抗细菌毒力策略以对抗细菌介导的疾病。
Nat Rev Drug Discov. 2010 Feb;9(2):117-28. doi: 10.1038/nrd3013. Epub 2010 Jan 18.

引用本文的文献

1
Breaking Barriers: Exploiting Envelope Biogenesis and Stress Responses to Develop Novel Antimicrobial Strategies in Gram-Negative Bacteria.突破障碍：利用包膜生物发生和应激反应开发针对革兰氏阴性菌的新型抗菌策略
Pathogens. 2024 Oct 11;13(10):889. doi: 10.3390/pathogens13100889.
2
Dose Individualisation of Antimicrobials from a Pharmacometric Standpoint: The Current Landscape.从药代动力学角度看抗菌药物的个体化用药：现状。
Drugs. 2024 Oct;84(10):1167-1178. doi: 10.1007/s40265-024-02084-7. Epub 2024 Sep 6.
3
Combatting Antibiotic-Resistant : Discovery of TST1N-224, a Potent Inhibitor Targeting Response Regulator VraRC, through Pharmacophore-Based Screening and Molecular Characterizations.对抗抗生素耐药性：通过基于药效团的筛选和分子特征研究发现针对反应调节子 vraRC 的强效抑制剂 TST1N-224。
J Chem Inf Model. 2024 Aug 12;64(15):6132-6146. doi: 10.1021/acs.jcim.4c01046. Epub 2024 Jul 30.
4
CpxA/R-Controlled Nitroreductase Expression as Target for Combinatorial Therapy against Uropathogens by Promoting Reactive Oxygen Species Generation.CpxA/R- 调控硝基还原酶表达作为通过促进活性氧生成治疗泌尿道病原体的联合治疗靶点。
Adv Sci (Weinh). 2023 Sep;10(25):e2300938. doi: 10.1002/advs.202300938. Epub 2023 Jul 5.
5
Targeting multidrug resistant infections with bacterial histidine kinase inhibitors.用细菌组氨酸激酶抑制剂靶向多重耐药感染
Chem Sci. 2023 Apr 11;14(19):5028-5037. doi: 10.1039/d2sc05369a. eCollection 2023 May 17.
6
In Vivo Role of Two-Component Regulatory Systems in Models of Urinary Tract Infections.双组分调节系统在尿路感染模型中的体内作用
Pathogens. 2023 Jan 10;12(1):119. doi: 10.3390/pathogens12010119.
7
Functional Annotation of Hypothetical Proteins From the B13 Strain and Its Association With Pathogenicity.来自B13菌株的假定蛋白质的功能注释及其与致病性的关联。
Bioinform Biol Insights. 2022 Aug 6;16:11779322221115535. doi: 10.1177/11779322221115535. eCollection 2022.
8
Sensing Host Health: Insights from Sensory Protein Signature of the Metagenome.感知宿主健康：来自宏基因组感应蛋白特征的新见解。
Appl Environ Microbiol. 2022 Aug 9;88(15):e0059622. doi: 10.1128/aem.00596-22. Epub 2022 Jul 13.
9
The W-Acidic Motif of Histidine Kinase WalK Is Required for Signaling and Transcriptional Regulation in .组氨酸激酶WalK的W-酸性基序是[具体生物名称未给出]中信号传导和转录调控所必需的。
Front Microbiol. 2022 Apr 26;13:820089. doi: 10.3389/fmicb.2022.820089. eCollection 2022.
10
Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients.致癌病毒的口腔脱落改变了HIV阳性患者的口腔微生物群。
Front Microbiol. 2022 Apr 19;13:882520. doi: 10.3389/fmicb.2022.882520. eCollection 2022.

本文引用的文献

1
Salmonella entry into mammalian cells: different yet converging signal transduction pathways?沙门氏菌进入哺乳动物细胞：不同但趋同的信号转导途径？
Trends Cell Biol. 1994 Jun;4(6):196-9. doi: 10.1016/0962-8924(94)90136-8.
2
Bacterial two-component signalling as a therapeutic target in drug design. Inhibition of NRII by the diphenolic methanes (bisphenols).细菌双组分信号传导作为药物设计中的治疗靶点。双酚类化合物（二酚甲烷）对NRII的抑制作用。
Adv Exp Med Biol. 1998;456:269-86. doi: 10.1007/978-1-4615-4897-3_14.
3
From the Centers for Disease Control and Prevention. Update: Staphylococcus aureus with reduced susceptibility to vancomycin--United States, 1997.来自美国疾病控制与预防中心。更新：对万古霉素敏感性降低的金黄色葡萄球菌——美国，1997年。
JAMA. 1997 Oct 8;278(14):1145-6.
4
Update: Staphylococcus aureus with reduced susceptibility to vancomycin--United States, 1997.最新消息：对万古霉素敏感性降低的金黄色葡萄球菌——美国，1997年
MMWR Morb Mortal Wkly Rep. 1997 Sep 5;46(35):813-5.
5
Impact of a vancomycin restriction policy on use and cost of vancomycin and incidence of vancomycin-resistant Enterococcus.万古霉素限制政策对万古霉素使用及成本以及耐万古霉素肠球菌发生率的影响
Ann Pharmacother. 1997 Sep;31(9):970-3. doi: 10.1177/106002809703100902.
6
Transcriptional regulation of the Enterococcus faecium BM4147 vancomycin resistance gene cluster by the VanS-VanR two-component regulatory system in Escherichia coli K-12.粪肠球菌BM4147万古霉素抗性基因簇在大肠杆菌K-12中由VanS-VanR双组分调节系统进行的转录调控。
J Bacteriol. 1997 Sep;179(18):5903-13. doi: 10.1128/jb.179.18.5903-5913.1997.
7
Mutational characterization of promoter regions recognized by the Salmonella dublin virulence plasmid regulatory protein SpvR.都柏林沙门氏菌毒力质粒调控蛋白SpvR识别的启动子区域的突变特征分析
J Bacteriol. 1997 Sep;179(17):5398-406. doi: 10.1128/jb.179.17.5398-5406.1997.
8
Molecular epidemiology and antibiotic susceptibility of enterococci in Cincinnati, Ohio: a prospective citywide survey.俄亥俄州辛辛那提市肠球菌的分子流行病学及抗生素敏感性：一项全市范围的前瞻性调查。
J Clin Microbiol. 1997 Sep;35(9):2342-7. doi: 10.1128/jcm.35.9.2342-2347.1997.
9
High-resolution NMR structure and backbone dynamics of the Bacillus subtilis response regulator, Spo0F: implications for phosphorylation and molecular recognition.枯草芽孢杆菌应答调节蛋白Spo0F的高分辨率核磁共振结构与主链动力学：对磷酸化和分子识别的影响
Biochemistry. 1997 Aug 19;36(33):10015-25. doi: 10.1021/bi970816l.
10
Resistance determinants for beta-lactam antibiotics in laboratory mutants of Streptococcus pneumoniae that are involved in genetic competence.肺炎链球菌实验室突变体中与遗传感受态相关的β-内酰胺类抗生素抗性决定因素。
Microb Drug Resist. 1996 Summer;2(2):187-91. doi: 10.1089/mdr.1996.2.187.