Oades R D
University Clinic for Child and Adolescent Psychiatry (RLHK), Essen, Germany.
Behav Brain Res. 1998 Jul;94(1):83-95. doi: 10.1016/s0166-4328(97)00172-1.
This article considers deficits in the selective aspects of perception underlying symptoms of impaired attention and impulsivity in children with attention-deficit hyperactivity syndrome (ADHD) in terms of frontal and temporal lobe function and cerebral asymmetry. Tomographic studies suggest a disturbed fronto-striatal function, but have neglected limbic contributions under activating conditions and are equivocal on the nature of apparent lateralized differences. Neuropsychological and psychophysiological studies suggest that early and late stages of information processing are affected in both the frontal and temporal lobes and imply impaired intercortical dialog. Given the evidence for a normal specialization in global processing in the right and the processing of details in the left hemisphere, the lateralized impairment may progress from situational ADHD (impaired selective aspects of perception on the right) to pervasive ADHD (additional impairment in decision-making on the left). Accordingly some ADHD children may experience an early negative neurodevelopmental influence that only appears as the brain region matures while others show a delayed development of CNS function.
本文从额叶和颞叶功能以及大脑不对称性的角度，探讨了注意缺陷多动障碍（ADHD）儿童注意力受损和冲动症状背后的选择性感知缺陷。断层扫描研究表明存在额叶 - 纹状体功能紊乱，但忽视了激活状态下边缘系统的作用，并且对于明显的侧化差异的性质存在争议。神经心理学和心理生理学研究表明，额叶和颞叶的信息处理早期和晚期阶段均受到影响，这意味着皮质间对话受损。鉴于有证据表明右半球在整体处理方面具有正常的特化，而左半球在细节处理方面具有正常的特化，这种侧化损伤可能从情境性ADHD（右侧选择性感知受损）发展为广泛性ADHD（左侧决策能力进一步受损）。因此，一些ADHD儿童可能经历早期的负面神经发育影响，这种影响只有在脑区成熟时才会显现，而另一些儿童则表现为中枢神经系统功能发育延迟。
