从鸡矢藤中分离得到的 5 个新的酚苷类化合物。
Five new phenolic glycosides from Hedyotis scandens.
机构信息
Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China.
出版信息
Bioorg Med Chem Lett. 2013 Mar 1;23(5):1379-82. doi: 10.1016/j.bmcl.2012.12.077. Epub 2013 Jan 5.
Five new phenolic glycosides, hedyotosides A-E (1-5), including a new cyanogenic glycoside (1), along with 10 known compounds (6-15) were isolated from the whole plants of Hedyotis scandens. The structures of compounds 1-5 were established by extensive spectroscopic analyses and acid hydrolysis. All the isolated compounds were evaluated for their in vitro antiviral activity against respiratory syncytial virus (RSV) with cytopathic effect (CPE) reduction assay. Compounds 6 and 15 showed anti-RSV effects with IC(50) values of 20 and 25 μg/mL, respectively.
从攀援地菍全株中分离得到了 5 个新的酚糖苷，分别为地菍苷 A-E（1-5），包括一个新的氰苷（1），以及 10 个已知化合物（6-15）。通过广泛的光谱分析和酸水解确定了化合物 1-5 的结构。所有分离得到的化合物均采用细胞病变效应（CPE）减少法进行了体外抗呼吸道合胞病毒（RSV）活性评价。化合物 6 和 15 对 RSV 的抑制作用较强，IC50 值分别为 20 和 25μg/mL。
Zotero 插件