Sersa G, Stabuc B, Cemazar M, Jancar B, Miklavcic D, Rudolf Z
Institute of Oncology, Ljubljana, Slovenia.
Eur J Cancer. 1998 Jul;34(8):1213-8. doi: 10.1016/s0959-8049(98)00025-2.
This study was aimed at assessing the response to electrochemotherapy with cisplatin of cutaneous tumour nodules in patients with malignant melanoma, squamous cell carcinoma and basal cell carcinoma. In 4 patients, 30 tumour nodules of different sizes were treated; five without treatment, one with electric pulses, five with cisplatin injected intratumorally and 19 with electrochemotherapy, i.e. intratumoral administration of cisplatin followed by delivery of electric pulses to the tumour nodule. After 4 weeks, a complete response (CR) in all 19 electrochemotherapy treated nodules was obtained. All electrochemotherapy treated nodules remained in CR (range 7-11 months), regardless of histological type, except for the metastasis of a squamous cell carcinoma that progressed after 9 months. CR was also obtained in two of five tumour nodules treated with cisplatin intratumorally, but the other three nodules progressed within 3-7 months. Exposure of the tumour nodule to electric pulses without cisplatin treatment had no effect on tumour growth. Electrochemotherapy was well tolerated by all patients and a good cosmetic effect was obtained, with only minimal scarring and a slight depigmentation of the skin. Electrochemotherapy with cisplatin has proved to be effective in patients with cutaneous tumour nodules. Furthermore, electrochemotherapy is easy to perform and can be carried out on an out-patient basis.
本研究旨在评估恶性黑色素瘤、鳞状细胞癌和基底细胞癌患者皮肤肿瘤结节对顺铂电化学疗法的反应。对4例患者的30个不同大小的肿瘤结节进行了治疗；5个未治疗，1个接受电脉冲治疗，5个瘤内注射顺铂，19个接受电化学疗法，即瘤内给予顺铂后对肿瘤结节施加电脉冲。4周后，19个接受电化学疗法治疗的结节均获得完全缓解（CR）。除1例鳞状细胞癌转移在9个月后进展外，所有接受电化学疗法治疗的结节均维持CR状态（7 - 11个月）。瘤内注射顺铂治疗的5个肿瘤结节中有2个也获得了CR，但另外3个结节在3 - 7个月内进展。未用顺铂治疗仅对肿瘤结节施加电脉冲对肿瘤生长无影响。所有患者对电化学疗法耐受性良好，且获得了良好的美容效果，仅留下轻微瘢痕和皮肤轻度色素脱失。顺铂电化学疗法已被证明对皮肤肿瘤结节患者有效。此外，电化学疗法操作简便，可在门诊进行。
