通过碳-13核磁共振揭示的红曲霉丝状真菌中桔霉素的生物合成途径。
Biosynthetic pathway of citrinin in the filamentous fungus monascus ruber as revealed by 13C nuclear magnetic resonance.
作者信息
Hajjaj H, Klaebe A, Loret MO, Goma G, Blanc PJ, Francois J
机构信息
Centre Bioingenierie Gilbert Durand, CNRS UMR 5504, LA INRA, Institut National des Sciences Appliquees de Toulouse, Complexe Scientifique de Rangueil, Toulouse, France.
出版信息
Appl Environ Microbiol. 1999 Jan;65(1):311-4. doi: 10.1128/AEM.65.1.311-314.1999.
Abstract
Carbon isotope distribution of [13C]citrinin from Monascus ruber incubated with [13C]acetate revealed that the biosynthesis of the toxin originated from a tetraketide, instead of a pentaketide as has been shown for Penicillium and Aspergillus species. The production of polyketide red pigments and citrinin by M. ruber may therefore be regulated at the level of the tetraketide branch point.
摘要
用[¹³C]乙酸盐培养的红曲霉中[¹³C]桔霉素的碳同位素分布表明，该毒素的生物合成起源于四酮化合物，而非如青霉属和曲霉属物种那样起源于五酮化合物。因此，红曲霉中聚酮类红色素和桔霉素的产生可能在四酮化合物分支点水平受到调控。
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