Pour P, Kmoch N, Greiser E, Mohr U, Althoff J, Cardesa A
J Natl Cancer Inst. 1976 May;56(5):931-5. doi: 10.1093/jnci/56.5.931.
Syrian hamsters from two colonies [Eppley colony (EC); Hannover colony (HC)] were examined for spontaneous neoplastic and noneoplastic diseases. Significant differences were found in tumor incidence (30%, EC' 42%, HC), occurrence of malignant neoplasms (15%, EC; 32%, HC), appearance of multiple primary tumors in different organs (42%, EC; 30%, HC), average survival rates of tumor-bearing animals, organ distribution and histologic types, and average survival rates of all animals. The frequencies of nonneoplastic diseases also varied between the two colonies. The findings indicated a need for precise histologic evaluation to generate information for comparative purposes regarding the use of hamsters in experimental pathology and carcinogenesis studies.
对来自两个种群[埃普利种群（EC）；汉诺威种群（HC）]的叙利亚仓鼠进行了自发性肿瘤和非肿瘤性疾病检查。在肿瘤发生率（EC为30%，HC为42%）、恶性肿瘤的发生情况（EC为15%，HC为32%）、不同器官中多发原发性肿瘤的出现情况（EC为42%，HC为30%）、荷瘤动物的平均存活率、器官分布和组织学类型以及所有动物的平均存活率方面发现了显著差异。两个种群之间非肿瘤性疾病的发生率也有所不同。这些发现表明，需要进行精确的组织学评估，以便为实验病理学和致癌作用研究中仓鼠的使用提供用于比较目的的信息。
