Hsieh A, Perkins E G
Lipids. 1976 Oct;11(10):763-8. doi: 10.1007/BF02533052.
Methyl esters of dimeric fatty acids were prepared by fractionating a mixture of conjugated linoleic and oleic acids that was heated for 24 hr at 300 C in the absence of air. Rats fed diets containing less than 1% dimers showed no significant difference (P less than 0.05) in the growth rate, feed efficiency, liver:body weight ratio, and lipid:liver weight ratio from those fed normal diets. A lymph cannulation study using 14C labeled dimers showed that ca. 0.4% of the dimers fed were absorbed within 12 hr and were transported as free acids in the lymph. Within a 28 hr period, 2% of the labeled dimers fed by gastric intubation were oxidized to 14CO2, and 1% radioactivity was recovered from the urine. The metabolism of methyl oleate appeared normal for rats prefed diets containing dimers.
二聚脂肪酸甲酯是通过将共轭亚油酸和油酸的混合物在无空气条件下于300℃加热24小时后进行分馏制备的。喂食含二聚体低于1%日粮的大鼠，其生长速率、饲料效率、肝脏与体重比以及脂质与肝脏重量比与喂食正常日粮的大鼠相比，无显著差异（P<0.05）。一项使用14C标记二聚体的淋巴插管研究表明，喂食的二聚体约0.4%在12小时内被吸收，并以游离酸形式在淋巴中运输。在28小时内，经胃插管喂食的标记二聚体中有2%被氧化为14CO2，1%的放射性从尿液中回收。对于预先喂食含二聚体日粮的大鼠，油酸甲酯的代谢似乎正常。
