Tsegaye A, Messele T, Tilahun T, Hailu E, Sahlu T, Doorly R, Fontanet A L, Rinke de Wit T F
Ethiopian-Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia.
Clin Diagn Lab Immunol. 1999 May;6(3):410-4. doi: 10.1128/CDLI.6.3.410-414.1999.
A cross-sectional survey was carried out with 485 healthy working adult Ethiopians who are participating in a cohort study on the progression of human immunodeficiency virus type 1 (HIV-1) infection to establish hematological reference ranges for adult HIV-negative Ethiopians. In addition, enumeration of absolute numbers and percentages of leukocyte subsets was performed for 142 randomly selected HIV-negative individuals. Immunological results were compared to those of 1,356 healthy HIV-negative Dutch blood donor controls. Immunohematological mean values, medians, and 95th percentile reference ranges were established. Mean values were as follows: leukocyte (WBC) counts, 6.1 x 10(9)/liter (both genders); erythrocyte counts, 5.1 x 10(12)/liter (males) and 4.5 x 10(12)/liter (females); hemoglobin, 16.1 (male) and 14.3 (female) g/dl; hematocrit, 48.3% (male) and 42.0% (female); platelets, 205 x 10(9)/liter (both genders); monocytes, 343/microl; granulocytes, 3, 057/microl; lymphocytes, 1,857/microl; CD4 T cells, 775/microl; CD8 T cells, 747/microl; CD4/CD8 T-cell ratio, 1.2; T cells, 1, 555/microl; B cells, 191/microl; and NK cells, 250/microl. The major conclusions follow. (i) The WBC and platelet values of healthy HIV-negative Ethiopians are lower than the adopted reference values of Ethiopia. (ii) The absolute CD4 T-cell counts of healthy HIV-negative Ethiopians are considerably lower than those of the Dutch controls, while the opposite is true for the absolute CD8 T-cell counts. This results in a significantly reduced CD4/CD8 T-cell ratio for healthy Ethiopians, compared to the ratio for Dutch controls.
对485名参与1型人类免疫缺陷病毒（HIV-1）感染进展队列研究的健康埃塞俄比亚成年工作者进行了横断面调查，以确定成年HIV阴性埃塞俄比亚人的血液学参考范围。此外，对142名随机选择的HIV阴性个体进行了白细胞亚群绝对数量和百分比的计数。将免疫学结果与1356名健康HIV阴性荷兰献血者对照的结果进行比较。建立了免疫血液学平均值、中位数和第95百分位数参考范围。平均值如下：白细胞（WBC）计数，6.1×10⁹/升（男女均如此）；红细胞计数，5.1×10¹²/升（男性）和4.5×10¹²/升（女性）；血红蛋白，16.1（男性）和14.3（女性）克/分升；血细胞比容，48.3%（男性）和42.0%（女性）；血小板，205×10⁹/升（男女均如此）；单核细胞，343/微升；粒细胞，3057/微升；淋巴细胞，1857/微升；CD4 T细胞，775/微升；CD8 T细胞，747/微升；CD4/CD8 T细胞比值，1.2；T细胞，1555/微升；B细胞，191/微升；NK细胞，250/微升。主要结论如下：（i）健康HIV阴性埃塞俄比亚人的WBC和血小板值低于埃塞俄比亚采用的参考值。（ii）健康HIV阴性埃塞俄比亚人的绝对CD4 T细胞计数明显低于荷兰对照，而绝对CD8 T细胞计数则相反。与荷兰对照的比值相比，健康埃塞俄比亚人的CD4/CD8 T细胞比值显著降低。
