Walling G A, Visscher P M, Andersson L, Rothschild M F, Wang L, Moser G, Groenen M A, Bidanel J P, Cepica S, Archibald A L, Geldermann H, de Koning D J, Milan D, Haley C S
Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS, United Kingdom.
Genetics. 2000 Jul;155(3):1369-78. doi: 10.1093/genetics/155.3.1369.
For many species several similar QTL mapping populations have been produced and analyzed independently. Joint analysis of such data could be used to increase power to detect QTL and evaluate population differences. In this study, data were collated on almost 3000 pigs from seven different F(2) crosses between Western commercial breeds and either the European wild boar or the Chinese Meishan breed. Genotypes were available for 31 markers on chromosome 4 (on average 8.3 markers per population). Data from three traits common to all populations (birth weight, mean backfat depth at slaughter or end of test, and growth rate from birth to slaughter or end of test) were analyzed for individual populations and jointly. A QTL influencing birth weight was detected in one individual population and in the combined data, with no significant interaction of the QTL effect with population. A QTL affecting backfat that had a significantly greater effect in wild boar than in Meishan crosses was detected. Some evidence for a QTL affecting growth rate was detected in all populations, with no significant differences between populations. This study is the largest F(2) QTL analysis achieved in a livestock species and demonstrates the potential of joint analysis.
对于许多物种而言，已经独立构建并分析了多个相似的QTL定位群体。对这些数据进行联合分析可用于提高检测QTL的效能并评估群体差异。在本研究中，整理了来自西方商业品种与欧洲野猪或中国梅山猪之间七个不同F2杂交组合的近3000头猪的数据。获得了第4号染色体上31个标记的基因型（每个群体平均8.3个标记）。对所有群体共有的三个性状（出生体重、屠宰时或试验结束时的平均背膘厚度、出生至屠宰或试验结束时的生长速率）的数据分别进行了个体群体分析和联合分析。在一个个体群体和合并数据中检测到一个影响出生体重的QTL，该QTL效应与群体之间无显著交互作用。检测到一个影响背膘的QTL，其在野猪杂交组合中的效应显著大于在梅山猪杂交组合中的效应。在所有群体中均检测到一些影响生长速率的QTL的证据，群体间无显著差异。本研究是在一个家畜物种中完成的最大规模的F2 QTL分析，证明了联合分析的潜力。
