Malone S M, Iacono W G, McGue M
University of Minnesota, Minneapolis 55455, USA.
Psychophysiology. 2001 May;38(3):367-76.
The present study examined event-related potentials (ERPs) elicited by a visual discrimination task in a community sample of adult males with a lifetime diagnosis of alcohol dependence. Study participants were subtyped by the presence of additional comorbid disorders (antisocial personality, depression, and drug abuse or dependence). In all groups of alcohol-dependent subjects, even those without any additional comorbid disorders, P3 amplitude differed from that of a comparison group. Alcohol-dependent subjects with a diagnosis of illicit drug abuse or dependence, especially if they had antisocial personality as well, had the smallest amplitude responses. The amplitude profile of the P3 across the parietal electrodes used as active sites was flattened among alcoholic subjects, with P3 amplitude disproportionately reduced at the midline. Among alcoholic subjects with a lifetime diagnosis of depression, the flattened amplitude profile was due to elevated mean amplitude of the P3 at lateral leads, especially P4, relative to the comparison group. Alterations in ERP responses appear to be a general characteristic of alcoholism in men, although the presence of other comorbid disorders, particularly drug abuse or dependence together with antisocial personality, results in the greatest reductions in P3 amplitude.
本研究检测了终生诊断为酒精依赖的成年男性社区样本在视觉辨别任务中诱发的事件相关电位（ERP）。研究参与者根据是否存在其他共病障碍（反社会人格、抑郁以及药物滥用或依赖）进行亚型分类。在所有酒精依赖受试者组中，即使是那些没有任何其他共病障碍的受试者，P3波幅也与对照组不同。诊断为非法药物滥用或依赖的酒精依赖受试者，尤其是那些同时患有反社会人格的受试者，其波幅反应最小。在酒精依赖受试者中，用作活动部位的顶叶电极上P3的波幅分布变平，中线处P3波幅不成比例地降低。在终生诊断为抑郁的酒精依赖受试者中，波幅分布变平是由于相对于对照组，外侧导联尤其是P4导联处P3的平均波幅升高。ERP反应的改变似乎是男性酒精中毒的一个普遍特征，尽管存在其他共病障碍，特别是药物滥用或依赖与反社会人格同时存在时，会导致P3波幅最大程度的降低。
