Zhang J, Jiang S, Watson R R
College of Public Health, The University of Arizona Health Science Center, 1501 N Campbell Avenue, Tucson, AZ 85724-5155, USA.
Environ Health Perspect. 2001 Oct;109(10):1007-9. doi: 10.1289/ehp.011091007.
Sidestream cigarette smoke (SSCS) makes up about 85% of significantly toxic environmental tobacco smoke (ETS). Reactive oxygen species (ROS) in SSCS play an important role in the pathogenesis of a wide range of diseases. Interleukin-6 is a pro-inflammatory cytokine and is closely linked with pathology in cardiovascular disease and conditions that have an inflammatory base. Exposure to SSCS through a burning cigarette for 30 min/day, 5 days a week, for 4 months increased interleukin-6 production in spleen and lipid peroxide level in mouse liver. Our findings suggest that ROS induced by SSCS will promote hepatic lipid peroxidation and may also contribute to an increase in interleukin-6 cytokine production. Multiple antioxidants given as a dietary supplement significantly normalized interleukin-6 cytokine production and prevented hepatic lipid peroxidation. We conclude that the SSCS in moderate intake levels increased oxidation and promoted inflammatory cytokine interleukin-6 production, whereas antioxidants prevented these changes.
侧流香烟烟雾（SSCS）约占剧毒环境烟草烟雾（ETS）的85%。SSCS中的活性氧（ROS）在多种疾病的发病机制中起重要作用。白细胞介素-6是一种促炎细胞因子，与心血管疾病及具有炎症基础的病症的病理密切相关。每周5天、每天通过燃烧香烟暴露于SSCS 30分钟，持续4个月，可增加小鼠脾脏中白细胞介素-6的产生及肝脏中的脂质过氧化物水平。我们的研究结果表明，SSCS诱导的ROS会促进肝脏脂质过氧化，也可能导致白细胞介素-6细胞因子产生增加。作为膳食补充剂给予的多种抗氧化剂可显著使白细胞介素-6细胞因子产生恢复正常，并预防肝脏脂质过氧化。我们得出结论，中等摄入量的SSCS会增加氧化并促进炎性细胞因子白细胞介素-6的产生，而抗氧化剂可预防这些变化。
