Valletta E, Bertini M, Sette L, Braggion C, Pradal U, Zannoni M
Department of Pediatrics, University of Verona, Italy.
BMC Gastroenterol. 2001;1:13. doi: 10.1186/1471-230x-1-13. Epub 2001 Nov 6.
Bronchopulmonary manifestations of Crohn disease have been rarely described in children, including both subclinical pulmonary involvement and severe lung disease.
A 6.5-year-old girl is described with early recurrent bronchopulmonary symptoms both at presentation and in the quiescent phase of Crohn disease. Pulmonary function tests (lung volumes and flows, bronchial reactivity and carbon monoxide diffusing capacity) were normal. Bronchoalveolar cytology showed increased (30%) lymphocyte counts and bronchial biopsy revealed thickening of basal membrane and active chronic inflammation.
Clinical and histological findings in our young patient suggest involvement of both distal and central airways in an early phase of lung disease. The pathogenesis of Crohn disease-associated lung disorders is discussed with reference to the available literature. A low threshold for pulmonary evaluation seems to be advisable in all children with CD.
克罗恩病的支气管肺表现鲜有儿童病例报道，包括亚临床肺受累及严重肺部疾病。
本文描述了一名6.5岁女童，在克罗恩病发病期及缓解期均出现早期反复的支气管肺症状。肺功能测试（肺容积和气流、支气管反应性及一氧化碳弥散能力）均正常。支气管肺泡细胞学检查显示淋巴细胞计数增加（30%），支气管活检显示基底膜增厚及活动性慢性炎症。
我们这位年轻患者的临床和组织学检查结果提示，在肺部疾病早期远端和中央气道均受累。参考现有文献对克罗恩病相关肺部疾病的发病机制进行了讨论。对于所有克罗恩病患儿，似乎都建议降低肺部评估的阈值。
