粪肠球菌相关的暴发，有从猪传播给人的分子证据。
Enterococcus faecium-related outbreak with molecular evidence of transmission from pigs to humans.
作者信息
Lu Hong-Zhou, Weng Xin-Hua, Li Haijing, Yin You-Kuan, Pang Mao-Yin, Tang Yi-Wei
机构信息
Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, People's Republic of China.
出版信息
J Clin Microbiol. 2002 Mar;40(3):913-7. doi: 10.1128/JCM.40.3.913-917.2002.
Abstract
Between 24 July and 31 August 1998, thousands of domestic pigs died of hemorrhagic shock in three adjunct counties along the YangZi River in Jiangshu Province, China. From 28 July to 6 September 1998, 40 local farmers (36 males and 4 females, ages 23 to 78 years) were hospitalized with severe illness characterized by high fever, erythematous rash or petechiae, and profound lethargy after contact with sick pigs. Twelve (30%) of these patients died of respiratory failure and shock. Eleven bacterial isolates recovered from 11 blood and cerebrospinal fluid specimens collected from seven patients and two pigs were identified as Enterococcus faecium based on biochemical reactions and 16S rRNA gene sequence analysis. Both pig and human E. faecium isolates displayed indistinguishable antibiotic susceptibility and pulsed-field gel electrophoresis patterns. These data strongly suggest the spread of an outbreak of E. faecium-related sepsis from pigs to humans.
摘要
1998年7月24日至8月31日期间，中国江苏省长江沿岸三个附属县的数千头家猪死于失血性休克。1998年7月28日至9月6日，40名当地农民（36名男性和4名女性，年龄在23至78岁之间）因与病猪接触后出现严重疾病而住院，这些疾病的特征为高热、红斑疹或瘀点，以及深度嗜睡。其中12名（30%）患者死于呼吸衰竭和休克。根据生化反应和16S rRNA基因序列分析，从7名患者和2头猪的11份血液和脑脊液标本中分离出的11株细菌被鉴定为粪肠球菌。猪和人类的粪肠球菌分离株显示出无法区分的抗生素敏感性和脉冲场凝胶电泳图谱。这些数据有力地表明了与粪肠球菌相关的败血症疫情从猪传播到了人类。
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