Elsner A E, Burns S A, Weiter J J, Delori F C
Schepens Eye Research Institute, Boston, MA 02114, USA.
Vision Res. 1996 Jan;36(1):191-205. doi: 10.1016/0042-6989(95)00100-e.
The interaction of infrared light with the human ocular fundus, particularly sub-retinal structures, was studied in vivo. Visible and infra-red wavelengths and a scanning laser ophthalmoscope were used to acquire digital images of the human fundus. The contrast and reflectance of selected retinal and sub-retinal features were computed for a series of wavelengths or modes of imaging. Near infrared light provides better visibility than visible light for sub-retinal features. Sub-retinal deposits appear light and thickened; the optic nerve head, retinal vessels, and choroidal vessels appear dark. Contrast and visibility of features increases with increasing wavelength from 795 to 895 nm. Optimizing the mode of imaging improves the visibility of some structures. This new quantitative basis for near infrared imaging techniques can be applied to a wide range of imaging modalities for the study of pathophysiology and treatment in diseases affecting the retinal pigment epithelium and Bruch's membrane, such as age-related macular degeneration.
对红外光与人类眼底，特别是视网膜下结构的相互作用进行了体内研究。使用可见光和红外波长以及扫描激光检眼镜获取人类眼底的数字图像。针对一系列波长或成像模式计算了选定视网膜和视网膜下特征的对比度和反射率。对于视网膜下特征，近红外光比可见光具有更好的可见性。视网膜下沉积物显得明亮且增厚；视神经乳头、视网膜血管和脉络膜血管显得黑暗。随着波长从795纳米增加到895纳米，特征的对比度和可见性增加。优化成像模式可提高某些结构的可见性。这种近红外成像技术的新定量基础可应用于广泛的成像方式，以研究影响视网膜色素上皮和布鲁赫膜的疾病（如年龄相关性黄斑变性）的病理生理学和治疗。
