具有不同大环内酯类耐药机制的A组链球菌菌株的出现。
Emergence of group A streptococcus strains with different mechanisms of macrolide resistance.
作者信息
Bingen Edouard, Leclercq Roland, Fitoussi Frédéric, Brahimi Naïma, Malbruny Brigitte, Deforche Dominique, Cohen Robert
机构信息
Service de Microbiologie, Hôpital Robert Debré, Paris, France.
出版信息
Antimicrob Agents Chemother. 2002 May;46(5):1199-203. doi: 10.1128/AAC.46.5.1199-1203.2002.
Abstract
The mechanisms of resistance to macrolides in seven group A streptococcal (Streptococcus pyogenes) isolates that were the cause of pharyngitis in children who were unsuccessfully treated with azithromycin (10 mg/kg of body weight/day for 3 days) were evaluated. All posttreatment strains were found to be genetically related to the pretreatment isolates by random amplified polymorphism DNA analysis and pulsed-field gel electrophoresis. Two isolates had acquired either a mef(A) or an erm(B) gene, responsible for macrolide efflux and ribosomal modification, respectively. Three isolates displayed mutations in the gene encoding the L4 ribosomal protein that is part of the exit tunnel within the 50S subunit of the bacterial ribosome. In the two remaining posttreatment strains, the mechanisms of macrolide resistance could not be elucidated.
摘要
对七株A组链球菌（化脓性链球菌）分离株的大环内酯类耐药机制进行了评估，这些分离株是阿奇霉素治疗失败（10mg/kg体重/天，共3天）的儿童咽炎的病因。通过随机扩增多态性DNA分析和脉冲场凝胶电泳发现，所有治疗后的菌株与治疗前的分离株存在遗传相关性。两株分离株分别获得了mef(A)或erm(B)基因，分别负责大环内酯类外排和核糖体修饰。三株分离株在编码L4核糖体蛋白的基因中出现突变，该蛋白是细菌核糖体50S亚基出口通道的一部分。在其余两株治疗后的菌株中，大环内酯类耐药机制尚不清楚。
相似文献
1
Emergence of group A streptococcus strains with different mechanisms of macrolide resistance.具有不同大环内酯类耐药机制的A组链球菌菌株的出现。
Antimicrob Agents Chemother. 2002 May;46(5):1199-203. doi: 10.1128/AAC.46.5.1199-1203.2002.
2
Resistance to macrolides in clinical isolates of Streptococcus pyogenes due to ribosomal mutations.化脓性链球菌临床分离株因核糖体突变而对大环内酯类药物产生耐药性。
J Antimicrob Chemother. 2002 Jun;49(6):935-9. doi: 10.1093/jac/dkf038.
3
Emergence of macrolide-resistant Streptococcus pyogenes strains in French children.法国儿童中耐大环内酯类化脓性链球菌菌株的出现。
Antimicrob Agents Chemother. 2004 Sep;48(9):3559-62. doi: 10.1128/AAC.48.9.3559-3562.2004.
4
Development of macrolide resistance by ribosomal protein L4 mutation in Streptococcus pyogenes during miocamycin treatment of an eight-year-old Greek child with tonsillopharyngitis.在对一名患有扁桃体咽炎的8岁希腊儿童进行米卡霉素治疗期间，化脓性链球菌通过核糖体蛋白L4突变产生大环内酯耐药性。
Clin Microbiol Infect. 2003 Sep;9(9):966-9. doi: 10.1046/j.1469-0691.2003.00670.x.
5
Decline in macrolide resistance rates among Streptococcus pyogenes causing pharyngitis in children isolated in Italy.在意大利分离出的引起儿童咽炎的化脓性链球菌中，大环内酯类耐药率下降。
Eur J Clin Microbiol Infect Dis. 2015 Sep;34(9):1797-802. doi: 10.1007/s10096-015-2414-x. Epub 2015 May 30.
6
Macrolide resistance mechanisms among Streptococcus pneumoniae isolated over 6 years of Canadian Respiratory Organism Susceptibility Study (CROSS) (1998 2004).在加拿大呼吸道病原体药敏试验（CROSS，1998 - 2004年）的6年期间分离出的肺炎链球菌中的大环内酯类耐药机制。
J Antimicrob Chemother. 2007 Oct;60(4):733-40. doi: 10.1093/jac/dkm273. Epub 2007 Aug 2.
7
Macrolide-resistant genes of Streptococcus pyogenes isolated from the upper respiratory tract by polymerase chain reaction.通过聚合酶链反应从呼吸道分离出的化脓性链球菌的大环内酯抗性基因。
J Infect Chemother. 2004 Apr;10(2):115-20. doi: 10.1007/s10156-004-0302-x.
8
Macrolide-resistance genes in clinical isolates of Streptococcus pyogenes.化脓性链球菌临床分离株中的大环内酯类耐药基因。
Microb Drug Resist. 2002 Summer;8(2):129-32. doi: 10.1089/107662902760190671.
9
Detection of multiple macrolide- and lincosamide-resistant strains of Streptococcus pyogenes from patients in the Boston area.从波士顿地区患者中检测出多种对大环内酯类和林可酰胺类耐药的化脓性链球菌菌株。
J Clin Microbiol. 2004 Apr;42(4):1559-63. doi: 10.1128/JCM.42.4.1559-1563.2004.
10
Prevalence and characterization of macrolide resistance in clinical isolates of Streptococcus pneumoniae and Streptococcus pyogenes from North America.北美肺炎链球菌和化脓性链球菌临床分离株中大环内酯类耐药性的流行情况及特征
J Chemother. 2002 Jul;14 Suppl 3:25-30. doi: 10.1080/1120009x.2002.11782349.
引用本文的文献
1
The macrolide antibiotic renaissance.大环内酯类抗生素的复兴
Br J Pharmacol. 2017 Sep;174(18):2967-2983. doi: 10.1111/bph.13936. Epub 2017 Aug 10.
2
Resistance to Macrolide Antibiotics in Public Health Pathogens.公共卫生病原体对大环内酯类抗生素的耐药性
Cold Spring Harb Perspect Med. 2016 Oct 3;6(10):a025395. doi: 10.1101/cshperspect.a025395.
3
4
Contribution of exogenous genetic elements to the group A Streptococcus metagenome.外源遗传元件对 A 组链球菌元基因组的贡献。
PLoS One. 2007 Aug 29;2(8):e800. doi: 10.1371/journal.pone.0000800.
5
Phenotypic and genotypic characterization of Streptococcus pyogenes isolates displaying the MLSB phenotype of macrolide resistance in Spain, 1999 to 2005.1999年至2005年西班牙呈现大环内酯类耐药MLSB表型的化脓性链球菌分离株的表型和基因型特征
Antimicrob Agents Chemother. 2007 Apr;51(4):1228-33. doi: 10.1128/AAC.01054-06. Epub 2007 Jan 22.
6
M.SpyI, a DNA methyltransferase encoded on a mefA chimeric element, modifies the genome of Streptococcus pyogenes.M.SpyI是一种由mefA嵌合元件编码的DNA甲基转移酶，可修饰化脓性链球菌的基因组。
J Bacteriol. 2007 Feb;189(3):1044-54. doi: 10.1128/JB.01411-06. Epub 2006 Nov 3.
7
The use of macrolides in treatment of upper respiratory tract infections.大环内酯类药物在上呼吸道感染治疗中的应用。
Curr Allergy Asthma Rep. 2006 Mar;6(2):171-81. doi: 10.1007/s11882-006-0056-x.
8
Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus.肺炎链球菌核糖体蛋白L4对恶唑烷酮类、大环内酯类和氯霉素耐药的新机制。
Antimicrob Agents Chemother. 2005 Aug;49(8):3554-7. doi: 10.1128/AAC.49.8.3554-3557.2005.
9
Association between resistance to erythromycin and the presence of the fibronectin binding protein F1 gene, prtF1, in Streptococcus pyogenes isolates from German pediatric patients.德国儿科患者化脓性链球菌分离株中红霉素耐药性与纤连蛋白结合蛋白F1基因（prtF1）存在之间的关联。
Antimicrob Agents Chemother. 2005 Jul;49(7):2990-3. doi: 10.1128/AAC.49.7.2990-2993.2005.
10
The Use of Macrolides in Treatment of Upper Respiratory Tract Infections.大环内酯类药物在上呼吸道感染治疗中的应用。
Curr Infect Dis Rep. 2005 May;7(3):175-184. doi: 10.1007/s11908-005-0031-z.
本文引用的文献
1
Comparison of two dosages of azithromycin for three days versus penicillin V for ten days in acute group A streptococcal tonsillopharyngitis.两种剂量阿奇霉素三日疗法与青霉素V十日疗法治疗急性A组链球菌扁桃体咽炎的比较
Pediatr Infect Dis J. 2002 Apr;21(4):297-303. doi: 10.1097/00006454-200204000-00008.
2
Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae.肺炎链球菌中赋予对大环内酯类、克林霉素、链阳菌素和替利霉素耐药性的核糖体突变的多样性。
Antimicrob Agents Chemother. 2002 Jan;46(1):125-31. doi: 10.1128/AAC.46.1.125-131.2002.
3
High prevalence of erythromycin-resistant and clindamycin-susceptible (M phenotype) viridans group streptococci from pharyngeal samples: a reservoir of mef genes in commensal bacteria.咽拭子样本中红霉素耐药且克林霉素敏感（M表型）的草绿色链球菌患病率高：共生菌中mef基因的储存库。
J Antimicrob Chemother. 2001 Oct;48(4):592-4. doi: 10.1093/jac/48.4.592.
4
Complete genome sequence of an M1 strain of Streptococcus pyogenes.化脓性链球菌M1菌株的全基因组序列
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4658-63. doi: 10.1073/pnas.071559398.
5
Macrolide resistance in Peptostreptococcus spp. mediated by ermTR: possible source of macrolide-lincosamide-streptogramin B resistance in Streptococcus pyogenes.由ermTR介导的消化链球菌属对大环内酯类的耐药性：化脓性链球菌中可能的大环内酯-林可酰胺-链阳菌素B耐药性来源。
Antimicrob Agents Chemother. 2001 Feb;45(2):630-2. doi: 10.1128/AAC.45.2.630-632.2001.
6
Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America.来自东欧和北美的肺炎链球菌临床菌株中两种新的大环内酯类耐药机制。
Antimicrob Agents Chemother. 2000 Dec;44(12):3395-401. doi: 10.1128/AAC.44.12.3395-3401.2000.
7
Short course therapy with cefitbuten versus azithromycin in pediatric streptococcal pharyngitis.
Pediatr Infect Dis J. 2000 Oct;19(10):963-7. doi: 10.1097/00006454-200010000-00004.
8
Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage.23S核糖体RNA和核糖体蛋白L4中的突变导致了在体外经大环内酯类药物传代筛选出的肺炎球菌菌株产生耐药性。
Antimicrob Agents Chemother. 2000 Aug;44(8):2118-25. doi: 10.1128/AAC.44.8.2118-2125.2000.
9
Resistance to macrolides in Streptococcus pyogenes in France in pediatric patients.法国儿科患者中化脓性链球菌对大环内酯类药物的耐药性
Antimicrob Agents Chemother. 2000 Jun;44(6):1453-7. doi: 10.1128/AAC.44.6.1453-1457.2000.
10
Impact of azithromycin on oropharyngeal carriage of group A Streptococcus and nasopharyngeal carriage of macrolide-resistant Streptococcus pneumoniae.阿奇霉素对A组链球菌口咽部携带及耐大环内酯类肺炎链球菌鼻咽部携带的影响。
Pediatr Infect Dis J. 2000 Jan;19(1):41-6. doi: 10.1097/00006454-200001000-00009.
Zotero 插件