首发精神分裂症的认知功能
Cognitive functioning in first-episode schizophrenia.
作者信息
Addington Jean, Addington Donald
机构信息
Department of Psychiatry, University of Calgary, Calgary, Alta.
出版信息
J Psychiatry Neurosci. 2002 May;27(3):188-92.
OBJECTIVE
To compare the cognitive functioning of a sample of patients experiencing their first episode of schizophrenia with that of patients with an established schizophrenia illness.
DESIGN
Cross-sectional and longitudinal study.
SETTING
The Calgary Early Psychosis Treatment and Prevention Program and an outpatient clinic in a department of psychiatry at a university-affiliated hospital.
PARTICIPANTS
One hundred and eleven patients who were experiencing their first episode of schizophrenia and 76 outpatients with an established schizophrenia illness.
MEASURES
The Positive and Negative Syndrome Scale for schizophrenia was administered to all subjects to determine levels of positive and negative symptoms. Executive functioning, information processing, visual memory, and immediate and delayed verbal memory were assessed.
RESULTS
There were limited differences between the 2 groups in terms of cognitive functioning. Although the first-episode patients demonstrated generally superior scores, their performance was impaired.
CONCLUSIONS
These results support the findings of previous studies suggesting that first-episode patients demonstrate cognitive impairments similar to those of patients with an established schizophrenia illness.
目的
比较首次发作精神分裂症患者样本与已确诊精神分裂症患者的认知功能。
设计
横断面和纵向研究。
地点
卡尔加里早期精神病治疗与预防项目以及一所大学附属医院精神科的门诊诊所。
参与者
111名首次发作精神分裂症的患者和76名已确诊精神分裂症的门诊患者。
测量方法
对所有受试者使用精神分裂症阳性和阴性症状量表来确定阳性和阴性症状水平。评估执行功能、信息处理、视觉记忆以及即时和延迟言语记忆。
结果
两组在认知功能方面差异有限。尽管首次发作患者的得分总体上更高，但其表现仍有受损。
结论
这些结果支持了先前研究的发现，即首次发作患者表现出与已确诊精神分裂症患者相似的认知障碍。
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